JOURNAL 1959


Organic Communications
VOLUME & ISSUE
Available Online: May 18,2021
PAGES
p.1 - 12
DOI ADDRESS
http://doi.org/10.25135/acg.oc.103.21.02.1959
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Priyadarsini Pullagura
  • Madhavarao Vallabhaneni
  • Hanumatha Rao Addanki
  • Subramanyam Chennamsetty
  • Ranganayakulu Yenisetty
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


2-Styrylchromones have been synthesized successfully by using eco-friendly, recoverable and reusable PEG-400 as reaction medium in the presence of the catalytic amount of piperidine under warm conditions through  1,5-diphenylpenta-2,4-dien-1-ones as intermediates followed by oxidative cyclization with iodine in the same reaction vessel  starting from 2-hydroxyacetophenones and cinnamaldehydes. The synthesized compounds were characterized by some physical methods and spectral data like IR, NMR, and LCMS etc. In silico molecular docking study was performed for all the synthesized compounds to know their ability in inhibiting pancreatic α-amylase enzyme. In this study, the compounds 24, 25, 26 & 28 with binding energies, -8.7, -8.8, -8.6  and -8.4  kcal/mol respectively were found to be more active amongst the synthesized when compared with standard drug, acarbose (-8.2 kcal/mol).

KEYWORDS
  • 2-Styrylchromones,
  • eco-friendly
  • PEG-400
  • molecular docking
  • acarbose
  • α-amylase

SUPPORTING INFORMATION


Supporting Information
Download File 103-OC-2102-1959-SI.pdf (952.92 KB)