JOURNAL 2742
Organic Communications
Available Online: May 11,2023
p.1 - 8
http://doi.org/10.25135/acg.oc.149.2303.2742 (DOI number will be activated after the manuscript has been available in an issue.)
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GRAPHICAL ABSTRACT
ABSTRACT
By condensation from substituted carbonyl compounds and anthranilamide under toluene reflux conditions, a wide range of 2,3-dihydroquinazolin-4(1H)-ones were produced in fair to good yields with the use of a Lewis acid catalyst Zn(OAc)2•2H2O (10 mol%), which is inexpensive, accessible, and environmentally friendly. All the synthesized compounds were properly described using melting point, IR, NMR, and mass spectral studies, and the findings were compared with information from the earlier literature. The new method has a number of advantages over the traditional methods for the synthesis of divergent 2,3-dihydroquinazolin-4(1H)-ones, including a higher product conversion, a wide substrate range, and the absence of undesirable side products. Aliphatic, heteroaromatic and aromatic carbonyl compounds were well tolerated under the optimized reaction conditions.
KEYWORDS- Quinazoline
- 2,3-dihydroquinazolin-4(1H)-ones
- catalysis
- zinc acetate dihydrate (Zn(OAc)2.2H2O)
- cyclization
- heterocycles
