JOURNAL 2893


Organic Communications
VOLUME & ISSUE
Available Online: October 29,2023
PAGES
p.1 - 8
DOI ADDRESS
http://doi.org/10.25135/acg.oc.158.2309.2893
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Özge Çağlar Teknikel
  • Hatice Öğütcü
  • Doğukan Doyduk
  • Ali Dişli
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


In this study, a synthetic route to access unsymmetrical ditetrazoles was developed. By using this method, the first examples of unsymmetrical thioditetrazole compounds were synthesized. In vitro, antibacterial efficacy studies were carried out for all the thioditetrazoles and their precursor thiotetrazoles against ten bacteria. The synthesized compounds showed a strong antibacterial effect against pathogenic Gram-negative bacteria, especially Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa (up to 21 mm).

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KEYWORDS
  • Tetrazole
  • thiotetrazole
  • dithiotetrazole
  • antibacterial activity
  • antifungal activity

SUPPORTING INFORMATION


Supporting Information
Download File 158-OC-2309-2893-SI.pdf (886.14 KB)