Synthesis and antimicrobial activities of unsymmetrical thioditetrazoles and their precursor thiotetrazoles
Available Online: October 29,2023
p.1 - 8
http://doi.org/10.25135/acg.oc.158.2309.2893 (DOI number will be activated after the manuscript has been available in an issue.)
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In this study, a synthetic route to access unsymmetrical ditetrazoles was developed. By using this method, the first examples of unsymmetrical thioditetrazole compounds were synthesized. In vitro, antibacterial efficacy studies were carried out for all the thioditetrazoles and their precursor thiotetrazoles against ten bacteria. The synthesized compounds showed a strong antibacterial effect against pathogenic Gram-negative bacteria, especially Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa (up to 21 mm).
- antibacterial activity
- antifungal activity