JOURNAL 2027


Organic Communications
VOLUME & ISSUE
Available Online: July 17,2021
PAGES
p.1 - 65
DOI ADDRESS
http://doi.org/10.25135/acg.oc.105.21.03.2027
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Ensaf Alwan
  • Rafat Mohareb
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


IIn the present review, we discuss new and diverse methods for synthesizing chromene, coumarin, pyrimidine, pyridine, pyrazole, thiazole and thiophene derivatives from 1,3-diketones, according to Knoevenagel condensation, Michael addition, Hantzsch reaction, and Gewald’s reaction. Various catalysts and reagents were used to complete the cyclization processes. Most of the produced compounds showed remarkable activity against different types of cancer cell lines and toward Gram-negative and Gram-positive bacteria. Furthermore, anti-quorum sensing, in vitro COX-1 and COX-2 enzymatic inhibition assays were evalua

KEYWORDS
  • 1,3-Diketone
  • chromene
  • pyridine
  • thiophene
  • anti-tumors