Synthesis of biologically active chromene, coumarin, azole, azine and thiophene derivatives from 1,3-diketone
Available Online: July 17,2021
p.1 - 65
http://doi.org/10.25135/acg.oc.105.21.03.2027 (DOI number will be activated after the manuscript has been available in an issue.)
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IIn the present review, we discuss new and diverse methods for synthesizing chromene, coumarin, pyrimidine, pyridine, pyrazole, thiazole and thiophene derivatives from 1,3-diketones, according to Knoevenagel condensation, Michael addition, Hantzsch reaction, and Gewald’s reaction. Various catalysts and reagents were used to complete the cyclization processes. Most of the produced compounds showed remarkable activity against different types of cancer cell lines and toward Gram-negative and Gram-positive bacteria. Furthermore, anti-quorum sensing, in vitro COX-1 and COX-2 enzymatic inhibition assays were evaluaKEYWORDS