JOURNAL 3175


Records of Natural Products
VOLUME & ISSUE
Available Online: April 30,2024
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.456.2403.3175
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 178 times.
AUTHORS
  • Xin Dong
  • Lin-Chuan Jia
  • Hai-Quan Chai
  • Xiao-Xiao Liu
  • Lei Yang
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


One new cyclonerane sesquiterpene, 9,11-cycloneren-3,7-diol (1), along with four known ones, 11-cycloneren-3,7,10-triol (2), 9-cycloneren-3,7,11-triol (3), 11-methoxy-9-cycloneren-3,7-diol (4), and cyclonerodiol (5), were obtained from the extract of marine-derived fungus Trichoderma harzianum WH-22. The structure of 9,11-cycloneren-3,7-diol (1) was elucidated by comprehensive spectroscopic analysis, including 1D/2D NMR and HRESIMS data. 9,11-Cycloneren-3,7-diol (1) exhibited weak cytotoxicity against HeLa and HepG2 cancer cell lines with IC50 values of 68.2 and 59.7 μM, respectively.

KEYWORDS
  • Cyclonerane sesquiterpene
  • Trichoderma harzianum
  • structure elucidation
  • cytotoxic activity

SUPPORTING INFORMATION


Supporting Information
Download File 456-RNP-2403-3175-SI.pdf (1.18 MB)