A New Ergosterol-Type Steroid Isolated from the Nicotiana tabacum-Derived Endophytic Fungus Aspergillus sp. TE-65L

Short Report

JOURNAL 2909

Records of Natural Products
VOLUME & ISSUE
Available Online: November 04,2023
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.420.2309.2909
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Xin-Rong Huang
  • Chao-Nan Jiang
  • Tong Si
  • Peng Zhang
  • Zhong-feng Zhang
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Chemical study on the fungal strain Aspergillus sp. TE-65L, which was previously isolated from cultivated tobacco (Nicotiana tabacum L.), led to the production of four steroids including a new ergosterol-type steroid, namely aspergosterol A (1). Their chemical structures were established by detailed spectroscopic analysis of 1D/2D NMR and HRESIMS data. Compound 1 was found to possess anti-phytopathogenic activities against Alternaria alternate, Botrytis cinerea, and Fusarium oxysporum, with MIC values of 4, 8, and 16 μg/mL.

 KEYWORDS
  • Aspergillus sp.
  • endophytic fungus
  • secondary metabolite
  • steroid
  • antifungal activity

SUPPORTING INFORMATION

Supporting Information
Download File 420-RNP-2309-2909-SI.pdf (1.06 MB)