A New Ergosterol-Type Steroid Isolated from the Nicotiana tabacum-Derived Endophytic Fungus Aspergillus sp. TE-65L
Records of Natural Products
Available Online: November 04,2023
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http://doi.org/10.25135/rnp.420.2309.2909 (DOI number will be activated after the manuscript has been available in an issue.)
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Chemical study on the fungal strain Aspergillus sp. TE-65L, which was previously isolated from cultivated tobacco (Nicotiana tabacum L.), led to the production of four steroids including a new ergosterol-type steroid, namely aspergosterol A (1). Their chemical structures were established by detailed spectroscopic analysis of 1D/2D NMR and HRESIMS data. Compound 1 was found to possess anti-phytopathogenic activities against Alternaria alternate, Botrytis cinerea, and Fusarium oxysporum, with MIC values of 4, 8, and 16 μg/mL.KEYWORDS
- Aspergillus sp.
- endophytic fungus
- secondary metabolite
- antifungal activity