JOURNAL 2232


Records of Natural Products
VOLUME & ISSUE
Available Online: December 21,2021
PAGES
p.1 - 8
DOI ADDRESS
http://doi.org/10.25135/rnp.300.21.10.2232
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Qingmei Feng
  • Hong Zhang
  • Jing Wang
  • Hongbin Li
  • Lingxia Zhang
  • Erping Xu
  • Suiqing Chen
  • Zhimin Wang
  • Liping Dai
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


 

A new iridoid glycoside, cornusglucoside I (1), and a new natural product methyl 4-(3′,4′-dihydroxyphenyl)-4-oxobutanoate (2), together with two known isolated compounds (3-4) were obtained from the 30% ethanol extract of the wine-processed Corni fructus. Their structures were clarified by spectroscopic analysis and literature data. The absolute configuration of 1 was elucidated by ECD calculation. By evaluating the NO production induced by LPS in RAW 264.7 cells to assess the anti-inflammatory activities of isolated compounds. Among the tested compounds, compounds 3 and 4 exhibited stronger anti-inflammatory activity than the positive drug dexamethasone (6 μM), which may be potential anti-inflammatory drugs.

 

KEYWORDS
  • Iridoid glycoside
  • wine-processed Corni fructus
  • anti-inflammatory activity

SUPPORTING INFORMATION


Supporting Information
Download File 300-RNP-2110-2232-SI.pdf (1.5 MB)