A New Megastigmane Glycoside and Anti-Inflammatory Bibenzyls from the Stems of Dendrobium henanense

Short Report

JOURNAL 2626

Records of Natural Products
VOLUME & ISSUE
Available Online: March 10,2023
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.382.2211.2626
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Siyu Wu
  • Shihui Qin
  • Chuihao Kong
  • Renzhong Wang
  • Deling Wu
  • Fengqing Xu
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A new megastigmane glycoside, namely (9S)-O-β-D-glucopyranosyl-2,5-megastigmen-4-one (1), along with seven known bibenzyls (2-8) were isolated from the aerial stems of Dendrobium henanense. Their structures were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-, 2D-NMR and HR-MS. The anti-inflammatory activities of compounds 1-8 evaluated its anti-inflammatory activity by inhibiting the production of inflammatory cytokines such as NO, TNF-α and IL-6 in LPS-stimulated RAW264.7 macrophages. Compounds 3, 4, 6-8 exhibited moderated anti-inflammatory activity with IC50 values of below 100 µΜ.

 KEYWORDS
  • Dendrobium henanense
  • megastigmane glycoside
  • anti-inflammatory
  • RAW264.7 macrophages

SUPPORTING INFORMATION

Supporting Information
Download File 382-RNP-2211-2626-SI.pdf (3.11 MB)