JOURNAL 2138


Records of Natural Products
VOLUME & ISSUE
Available Online: August 24,2021
PAGES
p.1 - 4
DOI ADDRESS
http://doi.org/10.25135/rnp.276.21.07.2138
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Xin Yin
  • Yongqiang Zhou
  • Shuang Zhang
  • Ying Zhou
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Phytochemical investigation of the fruits of Rosa roxburghii resulted in the isolation of four organic acid derivatives and three phenylpropanoids, including a new organic acid derivative, Roxbuacidester A (1) and six known compounds (2-7). The structures of all isolates were established by 1D and 2D NMR spectra referring to the literatures, together with HR-MS spectrometric analysis. In addition, compounds 1 and 2 were evaluated for their inhibitory activities on nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in a RAW 264.7 cell line. Compounds 1 and 2 showed moderate inhibition of NO production with IC50 values of 46.8 ± 2.3 and 62.5 ± 3.7 μM, respectively.

KEYWORDS
  • Rosaceae
  • Rosa roxburghii
  • organic acid derivative

SUPPORTING INFORMATION


SciFinder-Roxbuacidester A
Download File SciFinder-Roxbuacidester A.pdf (435.22 KB)
Supporting Information
Download File 276-RNP-2107-2138-SI.pdf (1.19 MB)