JOURNAL 2068


Records of Natural Products
VOLUME & ISSUE
Available Online: July 23,2021
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.270.2105.2068
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 265 times.
AUTHORS
  • Nguyen Hai Dang
  • Le Nguyen Thanh
  • Do Hoang Giang
  • Nguyen Tien Dat
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


In the course of searching for bioactive components from a Vietnamese spice, the fruits of Amomum aromaticum, a new bicyclic nonane (1) and seven known compounds including 4 monoterpenes (2, 3, 5, 6), one fatty acid (4), and two steroids (7-8) were isolated. Their structures were determined on the basis of spectroscopic analysis. This is the first report of compounds tsaokoin (2), 1β,2α-dihydroxy-p-menth-5-ene (3), oleic acid (4), β-sitosterol (7), and daucosterol (8) in A. aromaticum. To evaluate the anti-inflammatory activities of the isolates, we measured their inhibitory activity against lipopolysaccharide-induced nitric oxide production in a RAW264.7 murine macrophage model. The new compound rel-(1S,5R,6S)-5-methoxybicyclo[4.3.0]non-2-ene-2-carbaldehyde (1) and tsaokoin (2) showed substantial anti-inflammatory effects, with IC50 values of 17.78 and 6.31 µM, respectively. Thus, A. aromaticum fruits could be a rich source for the discovery of anti-inflammatory agents.

KEYWORDS
  • Amomum aromaticum
  • bicyclic nonane
  • tsaokoin
  • anti-inflammation

SUPPORTING INFORMATION


Supporting Information
Download File 270-RNP-2105-2068-SI.pdf (1.16 MB)