JOURNAL 2158


Records of Natural Products
VOLUME & ISSUE
Available Online: October 09,2021
PAGES
p.1 - 7
DOI ADDRESS
http://doi.org/10.25135/rnp.282.2108.2158
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Vu Thi Kim Oanh
  • Huu Giap Tran
  • Thu Ha Bui
  • Thi Lan Phuong Diep
  • Thi Van Anh Nguyen
  • Le Nguyen Thanh
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Phytochemical study of Adinandra hainanensis stems led to the isolation of a new triterpene lupan-3β,20-dihydroxy-28-carbaldehyde (1) and eleven known compounds 2-12. The stems of A. hainanensis was rich in lupane-type triterpenes, especially betulinic acid (9) was abundant (around 0.45% w/w). The isolated triterpenes, including new compound 1 showed strong α-glucosidase inhibitory activity with IC50 values ranging of 2.27 ± 0.05 μg/mL to 12.25 ± 0.36 μg/mL. In the cytotoxic evaluation, betulinic acid, the major component, showed good cytotoxic activity against all tested cancer cell lines while new compound 1 was weakly active.

KEYWORDS
  • Adinandra hainanensis
  • lupane triterpene
  • betulinic acid
  • α-glucosidase
  • cytotoxicity

SUPPORTING INFORMATION


Supporting Information
Download File 282-RNP-2108-2158.pdf (740.6 KB)