JOURNAL 2465


Records of Natural Products
VOLUME & ISSUE
Available Online: August 06,2022
PAGES
p.1 - 9
DOI ADDRESS
http://doi.org/10.25135/rnp.346.2205.2465
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Chao Ding
  • Yuze Li
  • Ying Wu
  • Yu Sun
  • Fengrui Wang
  • Huawei Zhang
  • Yi Jiang
  • Dongdong Zhang
  • Xiaomei Song
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Two new compounds, butyl(Z)-3-((3R,4R)-5-(hydroxymethyl)-3,4-dimethyl-3,4-dihydro- 2H-pyran-6-yl)acrylate (1) and (2Z,4S)-4,5-dihydroxy-3,4-dimethylpent-2-enoic acid (2) along with seven known ones, stigmast-5,28(29)-dien-3β-ol (3), β-sitosterol (4), carotene (5), fraxetin (6), p-coumaric acid (7), cis-p-hydroxycinnamic acid (8), ferulic acid (9) were obtained from the whole plant of Pachysandra terminalis. The structures of these compounds were elucidated by comprehensive spectroscopic methods including 1D, 2D NMR, MS, IR and ECD data analysis. Notably, compounds 3 and 5~8 were isolated from genus Pachysandra for the first time. Moreover, compounds 1~3 and 6~8 were tested their cytotoxic activities against three cancer cells, however, only compound 1 showed inhibitory effect in SW620 cells with IC50 value of 47.7 μM.

KEYWORDS
  • Pachysandra terminalis
  • chemical composition
  • isolation and purification
  • steroids
  • fatty acids

SUPPORTING INFORMATION


Supporting Information
Download File 346-RNP-2205-2465-SI.pdf (1.89 MB)