Phenolic Bisabolanes from the Marine-Derived Fungus Aspergillus sp. MEA11

Short Report

JOURNAL 2454

Records of Natural Products
VOLUME & ISSUE
Available Online: January 04,2023
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.377.2202.2454
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Wei Xu
  • Xin Liu
  • Wenzhen Lin
  • Minghuang Ling
  • Chiming Guo
  • Hongyan Meng
  • Ying Guo
  • Xiaona Du
  • Ruzhen Liu
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

In our work, the deep sea sediment-derived fungus Aspergillus sp. MEA11 was examined for secondary metabolites. Chromatographic separations resulted in the identification of a new phenolic bisabolane (1) and seven known analogs (3-7 and 8a, 8b). The structures were determined by 1H, 13C NMR, and MS data. The known compounds were identified to be 11,12-dihydroxysydonic acid (2), hydroxysydonic acid (3), aspergoterpenin B (4), engyodontiumone J (5), sydowic acid (6), penicipyran A (7), 1-hydroxyboivinianic acid (8). The NMR data of 7 in methanol-d4 were reported for the first time. Compounds 6-8 exhibited inhibitory effect against α-glucosidase with IC50 values of 176, 89, 232 uM, which were more active than the positive control acabose.

 KEYWORDS
  • Phenolic bisabolanes
  • Aspergillus sp.

SUPPORTING INFORMATION

Supporting Information
Download File 377-RNP-2205-2454-SI.pdf (1.06 MB)