JOURNAL 2156


Records of Natural Products
VOLUME & ISSUE
Available Online: October 05,2021
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.280.2108.2156
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Ping Yang
  • Ji Song
  • Mi Zhang
  • Shiyun Jiao
  • Weifeng Dai
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Abstract:  A new polyacetylene alcohol, Fissistigmol A (1), along with four known polyacetylene alcohol compounds (2-5) were isolated from the aerial part of Fissistigma minuticalyx (McGr. et W. W. Sm.). Their structures were elucidated based on the spectroscopic evidence, mainly including NMR and induced ECD, and HRESIMS data. In addition, bioactivity assay showed that 1-5 showed notable nitric oxide (NO) inhibitory effects (IC50 < 10 μM) on the model of the lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.

KEYWORDS
  • Polyacetylene alcohol
  • Annonaceae
  • Fissistigma minuticalyx
  • nitric oxide (NO) inhibitory activity

SUPPORTING INFORMATION


Supporting Information
Download File 280-RNP-2108-2156-SI.pdf (1.5 MB)