JOURNAL 2250


Records of Natural Products
VOLUME & ISSUE
Available Online: December 21,2021
PAGES
p.1 - 10
DOI ADDRESS
http://doi.org/10.25135/rnp.298.21.10.2250
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 169 times.
AUTHORS
  • Youngseok Kim
  • Ha-neul Ju
  • Pilju Choi
  • Taejung Kim
  • Young-tae Park
  • Dae-hee Lee
  • Jungyeob Ham
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The compounds hydrangenol and hydrangenol 8-O-glucoside are abundant in Hydrangea macrophylla. This study investigated the effects of hydrangenol and hydrangenol 8-O-glucoside derived from H. macrophylla on atopic dermatitis (AD). Compared with hydrangenol 8-O-glucoside, hydrangenol resulted in more potent inhibition of interleukin 4 (IL-4) gene expression and β-hexosaminidase release, as well as more potent inhibition of the phosphorylation of signal transducer and activator of transcription 6 (STAT6). Ultra High-Performance Liquid Chromatography (UHPLC), the concentrations of hydrangenol were found to be lower than the concentration of hydrangenol 8-O-glucoside in H. macrophylla extracts. To increase the hydrangenol content of H. macrophylla extract, component conversion methods were studied. Conclusion, microwave processing was found to be the optimal method for deglycosylation.

KEYWORDS
  • Hydrangea macrophylla
  • hydrangenol
  • hydrangenol 8-O-glucoside
  • atopic dermatitis
  • microwave irradiation

SUPPORTING INFORMATION


Supporting Information
Download File 298-RNP-2111-2250-SI.pdf (538.92 KB)