JOURNAL 3038


Records of Natural Products
VOLUME & ISSUE
Available Online: April 30,2024
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.457.2401.3038
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Le Thi Tu Anh
  • Hoang Thai Dang
  • Nguyen Thi Thu Ha
  • Nguyen Thanh Tra
  • Nguyen Thi Thuy Linh
  • Ba Thi Cham
  • Bui Thi Thuy Luyen
  • Hoang Huy Do
  • Tiep Khac Nguyen
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Nine known compounds were isolated from the P. serrata roots and showed promising inhibitory activity against α-glucosidase. The molecular docking study of them was exhibited the 4-hydroxyl group in the aromatic ring of benzoic acid derivatives improves the bioactivity. Network pharmacology was performed to investigate the molecular mechanisms of isolated compounds and suggested that the insulin resistance pathway would be a primary mechanism of action. This is the first time the α-glucosidase inhibitors of P. serrata roots were reported.

KEYWORDS
  • Polyscias serrata
  • α-glucosidase inhibitor
  • molecular docking
  • network pharmacology

SUPPORTING INFORMATION


Supporting Information
Download File 457-RNP-2401-3038-SI.pdf (2.89 MB)