JOURNAL 1965


Records of Natural Products
VOLUME & ISSUE
Available Online: March 13,2021
PAGES
p.1 - 8
DOI ADDRESS
http://doi.org/10.25135/rnp.230.21.02.1965
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Penghua Shu
  • Huiqing Zhu
  • Wanrong Liu
  • Lingxiang Zhang
  • Junping Li
  • Mengzhu Yu
  • Yingying Fei
  • Shujing Cai
  • Ruihua Li
  • Xialan Wei
  • Wenhan Yi
  • Fugang Xiao
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A new hydrocinnamoyl glucoside, 1-O-(4-hydroxyhydrocinnamoyl)-β-D-glucopyranose (1), together with fifteen known glycosides, including two phenylethanoid glycosides (23), two cinnamoyl glycosides (45), six phenolic glycosides (611), one lignan glycoside (12) and four megastigmane glycosides (1316) were isolated from a 95% EtOH extract of the Typhonium giganteum rhizomes. The sixteen glycosides were structurally characterized by NMR, HRESIMS, enzymatic hydrolysis and comparison with literature. Upon evaluating inhibitory activities of compounds 116 against mushroom tyrosinase at 25 μM, compounds 10 and 11 exhibited obvious inhibitory activities, with %inhibition values of 20.94±0.59%, 23.28±1.09%, respectively, with arbutin used as the positive control (26.21±0.58%).

KEYWORDS
  • Typhonium giganteum
  • tyrosinase inhibitor
  • glycoside
  • arbutin

SUPPORTING INFORMATION


Supporting Information
Download File 230-RNP-2102-1965-SI.pdf (706.93 KB)