JOURNAL 2560


Records of Natural Products
VOLUME & ISSUE
Available Online: November 08,2022
PAGES
p.1 - 7
DOI ADDRESS
http://doi.org/10.25135/rnp.366.2208.2560
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 306 times.
AUTHORS
  • Qing Zhu
  • Can Yue Ouyang
  • Yang Liu
  • Zhangjun Xu
  • Ying Zhang
  • Ronghua Liu
  • Lanying Chen
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A new chalcone compound, methyl 5-cinnamoyl-2-hydroxy-4-methoxybenzoate (1), and a new cinnamylphenol compound, methyl 3-cinnamyl-5-hydroxy-4-methoxybenzoate (2) together with four known compounds (3-6) were obtained from the CH2Cl2 soluble fraction of Dalbergia melanoxylon. Their structures were elucidated by comprehensive spectral measurements, single crystal X-ray diffraction and literature data. According to the determination results of compound 1 and 2 on RAW 264.7 cell viability, the IC50 values of compounds 1-2 were 4.11 and 113.99 μg/mL, respectively. Compared with LPS model group, compound 1 and 2 could significantly reduce the release of NO in the concentration rages of 0.375~3.0 μg/mL and 10 μg/mL (P<0.01), and significantly inhibit the secretion of LDH with 1.5~3 μg/mL and 5~10 μg/mL.

KEYWORDS
  • Dalbergia melanoxylon
  • chalcone
  • cinnamylphenol
  • anti-inflammatory activity

SUPPORTING INFORMATION


Supporting Information
Download File 366-RNP-2208-2560-SI.pdf (2.04 MB)