JOURNAL 2447


Records of Natural Products
VOLUME & ISSUE
Available Online: August 06,2022
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.348.2204.2447
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 407 times.
AUTHORS
  • Yu Liu
  • Fan Yang
  • Xiaoqian Zhang
  • Ying Qiao
  • Wei Xu
  • Qin Li
  • Zhongbin Cheng
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Abstract: The fungal strain Aspergillus fumigatus CBC18132, isolated from deep-sea sediment, was investigated for secondary metabolites. Fermentation on rice medium followed by chromatographic separation led to the isolation of three polyketides (13) and nine alkaloids (413). The structures were determined by analyses of spectroscopic data (1H and 13C NMR, and MS data). The absolute configuration of the anthraquinone-derivative trypacidin was resolved for the first time by a combination of ECD and specific rotation calculation. All isolated compounds were inactive toward the -glucosidase at the initial concentration of 2 mM.

KEYWORDS
  • Aspergillus fumigatus
  • trypacidin
  • absolute configuration

SUPPORTING INFORMATION


Supporting Information
Download File 348-RNP-2204-2447-SI.pdf (1.88 MB)