JOURNAL 2593


Records of Natural Products
VOLUME & ISSUE
Available Online: October 29,2022
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.363.2210.2593
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Qian Chen
  • Yifang Chen
  • Ying Lu
  • Jianyong Zhao
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The marine-derived fungus SCZ-1 was cultured on a rice solid medium. The fermented materials was extracted using ethyl acetate to afford an extract, which was separated by repeated column chromatography to afford three polyketides and five alkaloids, including 2 new polyketides (1 and 2). The known compounds were identified to be penipyrol A (3), cyclopenin (4), cyclopenol (5), terretrione D (6), viridicatol (7), and viridicatin (8). The structures of 1 and 2 were determined by extensive analyses of spectroscopic data (1D and 2D NMR, and HRESIMS). The absolute configuration of 2 was assigned by comparing the experimental and calculated ECD spectra. Compound 1, bearing a two-carbon side chain at C-2, is seldom found among isocoumarins. The metabolites were screened for their inhibitions toward a-glucosidase, only compound 8 showed weak inhibitory effect with an IC50 value of 548 mM.

KEYWORDS
  • Marine fungus
  • Penicillium sp.
  • new polyketides

SUPPORTING INFORMATION


Supporting Information
Download File 363-RNP-2210-2593-SI.pdf (2.28 MB)