Polyketides and Alkaloids from the Fungus Penicillium sp.
Records of Natural Products
Available Online: October 29,2022
p.1 - 5
http://doi.org/10.25135/rnp.363.2210.2593 (DOI number will be activated after the manuscript has been available in an issue.)
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The marine-derived fungus SCZ-1 was cultured on a rice solid medium. The fermented materials was extracted using ethyl acetate to afford an extract, which was separated by repeated column chromatography to afford three polyketides and five alkaloids, including 2 new polyketides (1 and 2). The known compounds were identified to be penipyrol A (3), cyclopenin (4), cyclopenol (5), terretrione D (6), viridicatol (7), and viridicatin (8). The structures of 1 and 2 were determined by extensive analyses of spectroscopic data (1D and 2D NMR, and HRESIMS). The absolute configuration of 2 was assigned by comparing the experimental and calculated ECD spectra. Compound 1, bearing a two-carbon side chain at C-2, is seldom found among isocoumarins. The metabolites were screened for their inhibitions toward a-glucosidase, only compound 8 showed weak inhibitory effect with an IC50 value of 548 mM.KEYWORDS
- Marine fungus
- Penicillium sp.
- new polyketides