JOURNAL 2522


Records of Natural Products
VOLUME & ISSUE
Available Online: October 31,2022
PAGES
p.1 - 13
DOI ADDRESS
http://doi.org/10.25135/rnp.358.2207.2522
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Milan Kulić
  • Dragana Drakul
  • Dragana Sokolović
  • Jelena Kordić-Bojinović
  • Slobodan Milovanović
  • Duško Blagojević
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Satureja montana L. (SM) has a long traditional use as a spice and a medicine for various gastrointestinal disorders, including painful spasms and diarrhea. Contrary to conventional drugs, administration of SM and its extracts are considered safe. Previous studies have shown that the essential oils (EOs) of SM from different areas are rich in monoterpenes, sesquiterpenes, diterpens, and phenolic compounds, including flavonoids, tannins, and acids with great composition variability. Determination of composition of EO from Herzegovinian SM done by gas chromatography-flame ionization detection and gas chromatography mass spectrometry (GC-FID and GC/MS, respectively) revealed carvacrol as a primary substance followed by γ-terpinene, p-cymene, and β-caryophyllene. Ex vivo spasmolitic activity caused  by EO was evident in different types of isolated rat ileum function with the most potent effect on spontaneous activity followed by electrical field stimulation and KCl- and CaCl2-induced activity. SMEO produced in vivo antidiarreal activity on castor oil-induced diarrhea in young rats and showed the potential to cause a decrese water content in the feces of adult Wistar rats.This study indicates that effects of SM on the intestinum could be mediated through combination of Kv channel activation and Ca channel blockade, but additional mechanisms might be involved. The results of this study corroborate the traditional use of SM as antispasmodic, antidiarrheal, and antisecretory agents.

KEYWORDS
  • Satureja montana
  • antispasmodic
  • antidiarrheal

SUPPORTING INFORMATION


ethical committee approval

Approval of Ethical Comitte of Faculty of Medicine Foča No. 01-1090

Download File EC Satureja montana.pdf (192.68 KB)