JOURNAL 2236


Records of Natural Products
VOLUME & ISSUE
Available Online: December 17,2021
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.299.21.10.2236
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Huu Giap Tran
  • Mai Thao Vu
  • Thi Tu Oanh Nguyen
  • Thi Thoa Ha
  • Dang Diem Hong
  • Thi Hoai Thu Ngo
  • Thi Thom Le
  • Cam Ha Nguyen
  • Thi Minh Hang Nguyen
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Phytochemical investigation of Thraustochytrium aureum led to the isolation of eleven compounds including ergosterol (1), 7-dehydroporiferasterol (2), (22E,24R)-ethylcholesta-7,22-dien-3β,5α,6β-triol (3), poriferasterol glucoside (4), perlolyrine (5), pyrrolezanthine-6-methyl ether (6), 3-(3-aminopropyl)-6-[(4-hydroxyphenyl)methyl]-2,5-piperazinedione (7), 5-methyluracil (8), 1H-indole-3-carboxylic acid (9), adenosine (10), and p-hydroxybenzoic acid (11). Screening for α-glucosidase inhibitory, antimicrobial and cytotoxic activities of the extracts and isolated compounds were carried out. The n-hexane extract was the most active, which showed strong α-glucosidase inhibitory activity with IC50 of 48.22 μg/mL, inhibition against E. faecalis, S. aureus and C. albicans microorganism strains with MIC values of 128, 64 and 64 μg/mL, respectively. Compound 6 have shown to be the most active among isolated compounds, which inhibited α-glucosidase with IC50 value of 7.96 μg/mL; E. faecalis and C. albicans microorganism strains with MIC values of 64 and 16 μg/mL and inhibited the growth of A549, HepG2, MCF7 and LNCaP cancer cell lines with IC50 values of 62.26, 41.03, 57.21 and 43.23 μg/mL, respectively.

KEYWORDS
  • Thraustochytrium aureum
  • alkaloid
  • steroid
  • microalga
  • α-glucosidase

SUPPORTING INFORMATION


Supporting Information
Download File 299-RNP-2110-2236-SI.pdf (3.08 MB)