JOURNAL 2223


Records of Natural Products
VOLUME & ISSUE
Available Online: November 25,2021
PAGES
p.1 - 9
DOI ADDRESS
http://doi.org/10.25135/rnp.297.2110.2223
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Penghua Shu
  • Yuehui Luo
  • Huiqing Zhu
  • Yamin Li
  • Yingying Fei
  • Mengzhu Yu
  • Ting Xu
  • Yueyue Lou
  • Fugang Xiao
  • Jihong Huang
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Fourteen secondary metabolites, including one cinnamate derivative (1), three spirocyclic nortriterpenoids (24), three phenylethanoid glycosides (57), four lignans (811) and three phenolic compounds (1214) were isolated from the EtOH extract of Leonuri Fructus. Their structures were elucidated on the basis of 1D NMR, 2D NMR and HR-ESI-MS data analysis. All isolates were tested for their antioxidant, tyrosinase and acetylcholinesterase inhibitory activities. Most of them showed moderate antioxidant activities. Compounds 24 exhibited obvious inhibitory activities against mushroom tyrosinase at 25 μM, with %inhibition values of 49.36 ±2.69%, 43.43 ± 3.35%, 51.69 ± 2.81%, respectively, with arbutin used as the positive control (51.90 ± 2.57%). Compounds 3, 56 and 910 exhibited significant inhibitory activities against acetylcholinesterase, similar to the positive control, galantamine

KEYWORDS
  • Leonuri Fructus
  • Leonurus japonicus
  • nortriterpenoid
  • phenylethanoid glycoside
  • tyrosinase
  • acetylcholinesterase

SUPPORTING INFORMATION


Supporting Information
Download File 297-RNP-2110-2223-SI.pdf (1.9 MB)