JOURNAL 2466


Records of Natural Products
VOLUME & ISSUE
Available Online: July 28,2022
PAGES
p.1 - 10
DOI ADDRESS
http://doi.org/10.25135/rnp.347.2205.2466
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 132 times.
AUTHORS
  • Chenxiao Shen
  • Can Yue Ouyang
  • Ying Zhang
  • Qing Zhu
  • Ronghua Liu
  • Lanying Chen
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Two new sesquiterpenes (1R,5R,6R)-11-hydroxyl-drocostuslactone (1) and (1R,10S)- gibberodione A (2) were acquired from the leaves of Dalbergia odorifera. The structures of two new sesquiterpenes were revealed by broad NMR exploration, and X-ray crystallography analyses. In addition, the bioactivity assay showed that two compounds had potential anti-inflammatory activity with less toxicity (their IC50 values were 107.2 ± 4.02 and 54.64 ± 1.89 μg/mL), could significantly decrease the production of NO (P<0.01) with 8~16 and 1~2 μg/mL and inhibited LDH (P<0.01) with 1~16 and 1~2 μg/mL in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, respectively.

 

KEYWORDS
  • Dalbergia odorifera
  • sesquiterpenoids
  • anti-inflammatory activity

SUPPORTING INFORMATION


Supporting Information
Download File 347-RNP-2205-2466-SI.pdf (1.06 MB)