JOURNAL 2097


Records of Natural Products
VOLUME & ISSUE
Available Online: September 05,2021
PAGES
p.1 - 9
DOI ADDRESS
http://doi.org/10.25135/rnp.277.21.06.2097
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Nguyen Ngoc Tuan
  • Ping-chung Kuo
  • Vu Dinh Hoang
  • Vu Thi Hien
  • Le Dang Quang
  • Tran Trung Hieu
  • Yue-chiun Li
  • Nguyen Tan Thanh
  • Tian-shung Wu
  • Tran Dinh Thang
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Eleven chemical constituents, including one new limonoid trichilinin G (1), were identified from the fruit extracts of M. azedarach. The structure of 1 was established by various spectroscopic and mass spectrometric analyses. Among the eleven isolated compounds, trichilinin G (1) and meliatoxin B1 (2) were examined for their antifungal activity against Fusarium oxysporum, Magnaporthe grisea, Phytophthora spp. (PS), and P. capsici (PC). Limonoid 2 showed the best antifungal activity against PS (IC50 = 103.8 µg/mL) and PC (IC50 < 62.5 µg/mL) in a dose-dependent manner. While limonoid 1 exhibited a weak to moderate activity against these Phytophthora species, F. oxysporum and M. grisea were less sensitive to the two compounds tested. The inhibitory effects of trichilinin G on superoxide anion generation and elastase release by human neutrophils were also assessed in cellular model and did not show significant activity.

KEYWORDS
  • Triterpenoid
  • limonoid
  • trichilinin
  • antifungal
  • anti-inflammatory

SUPPORTING INFORMATION


Supporting Information
Download File 277-RNP-2106-2097-SI.pdf (7.29 MB)