JOURNAL 2486


Records of Natural Products
VOLUME & ISSUE
Available Online: September 22,2022
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.356.2206.2486
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Lijing Cai
  • Mengying Zhang
  • Jie He
  • Tingting Lin
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A new sesquiterpene, named todasinoid A (1), together with eight known compounds (2-9) were isolated from the roots of Toddalia asiatica. The gross structure of todasinoid A were established by analyses of the NMR and HRESIMS data. A comparison of the experimental ECD spectrum of 1 with the calculated ECD spectra for a model compound (1a) resolved the absolute configuration of 1. The known compounds were identified to be bullatantriol (2), aculeatin (3), 6-(3-ethoxy-2-hydroxy-3-methylbutyl)-5,7-dimethoxy-2H-1-benzopyran-2-one (4), trans-N-p-coumaroyltyramine (5), feruloyltyramine (6), b-sitosterol (7), sitosterol D-glucoside(8), 7α-hydroxysitosterol (9) by comparing the NMR data and specific rotations with reported data in literature. Compound 1 is an eremophilane-type sesquiterpenoid containing a mercaptolactate side-chain that is rarely found in nature. Compounds 2, 5, and 9 were isolated from this plant for the first time. Bioassay study revealed that compound 5 exhibited inhibitory effects against a-glucosidase with an IC50 of 320 mM, being more active than the positive control acarbose.

KEYWORDS
  • Toddalia asiatica
  • Todasinoid A
  • sesquiterpenoid
  • ECD calculation

SUPPORTING INFORMATION


Supporting Information
Download File 356-RNP-2206-2486-SI.pdf (972.31 KB)