Trichonafurin A: a New γ-Lactone Compound from the Marine-Derived Fungus Trichoderma atroviride ZW-7

Short Report

JOURNAL 2714

Records of Natural Products
VOLUME & ISSUE
Available Online: March 22,2023
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.388.2302.2714
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Lu-Di Zhai
  • Wei Gao
  • Li-Ting Liu
  • Ke Zhang
  • De-Liang Zhang
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A new γ-lactone compound, trichonafurin A (1), was obtained from the culture of Trichoderma atroviride ZW-7, an endophyte of the marine brown alga Sargassum thunbergii. Its structure was unambiguously assigned by detailed interpretation of 1D/2D NMR and HRESIMS data. Trichonafurin A (1) exhibited moderate cytotoxicity against HeLa and HepG2 cell lines with IC50 values of 20.2 and 32.1 μM, respectively.

 KEYWORDS
  • Trichoderma atroviride
  • secondary metabolites
  • cytotoxic activity

SUPPORTING INFORMATION

Supporting Information
Download File 388-RNP-2302-2714-SI.pdf (1.21 MB)