JOURNAL 2121


Records of Natural Products
VOLUME & ISSUE
Available Online: October 25,2021
PAGES
p.1 - 8
DOI ADDRESS
http://doi.org/10.25135/rnp.289.2106.2121
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Chi-I Chang
  • Cheng-Chi Chen
  • Sheng-Yang Wang
  • Jih-Jung Chen
  • Chiy-Rong Chen
  • Che-Yi Chao
  • Yueh-Hsiung Kuo
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Two new seco-abietanoids, 12-hydroxy-6-nor-5,6-secoabieta-8,11,13-trien-7-oic acid (1) and 7-hydroxy-7,8-secoabieta-8,12-diene-6,11,14-trione (3), together with one known seco-abietanoid, 12-hydroxy-6-nor-5-oxo-5,6-secoabieta-8,11,13-trien-7-al (2), were isolated from the methanol extract of the bark of Cryptomeria japonica. Their structures were elucidated by mean of spectroscopic analysis, as well as on  comparison of NMR data with those of known analogues. At a concentration of 50 μM, compounds 13 showed inhibitory activity toward xanthine oxidase by 38.2%, 55.9%, and 23.0%, respectively.

KEYWORDS
  • Cupressaceae
  • Cryptomeria japonica
  • bark
  • diterpenoid

SUPPORTING INFORMATION


Supporting Information
Download File 289-RNP-2106-2121-SI.pdf (1.81 MB)