Determination of Lidocaine HCl in commercially cream and injection forms by GC-FID method

Original Article

JOURNAL 2418

Bioorganic and Medicinal Chemistry Reports

VOLUME & ISSUE

Year: 2022 Issue: 1 January-June

PAGES

p.9 - 19

DOI ADDRESS

http://doi.org/10.25135/bmcr.27.2204.2418

STATISTICS

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AUTHORS

Alptuğ Atila
Yücel Kadioglu

GRAPHICAL ABSTRACT

ABSTRACT

In the present study, GC-FID method for the determination of lidocaine HCl in commercially creams and injection forms was developed and validated. The linearity of method was observed in the concentration range of 0.1-5.0 µg/mL. The accuracy (RE%) and precision (RSD%) values of the within-day and between-day of GC-FID method are less than 10.0% and 3.0%, respectively, and also limit of detection (LOD) and the limit of quantitation (LOQ) values were observed as 0.03 and 0.11 µg/mL, respectively. The analytical recovery value of lidocaine HCl was determined as 99.47% on average. As a result, it was concluded that the developed and validated GC-FID method can be easily used in routine analyzes in quality control laboratories.

KEYWORDS

Lidocaine HCl
local anesthesia
cream
injection
GC-FID Method