Organic Communications

A scientific open acces journal in the field of synthetic organic chemistry and polymers
Editor-in-Chief: Hasan Seçen
Book Review and Review Article Editor: Turan Ozturk
Synthetic Polymer Section Editor: Mehmet S. Eroglu

LATEST ARTICLES

Communication

Synthesis and in vitro activity of oleanane type derivatives against Chlamydia trachomatis

Org. Commun. (2019) 12:3 ; 169 - 175
by Oxana Kazakova , Liudmila Rubanik , Irina Smirnova , Olga Savinova , Anastasiya Petrova , Nikolay Poleschuk , Elmira Khusnutdinova , Eugene Boreko and Yuliya Kapustina

Modified synthesis of 3β-nicotinoyloxy-olean-12(13)-en-28-oic acid and 3-deoxy-3a-homo-3a-aza-28-hydroxy-olean-12(13)-en from natural occurring oleanolic acid is suggested. These compounds and two others of ursane and lupane type triterpenoids (3-oximino-urs-12-en-28-oic acid and 3-deoxy-3a-homo-3a-aza-28-hydroxy-lup-12(13)-en) were screened in vitro against Chlamydia trachomatis strain F-3271/Belarus/2015. Oleanane triterpenoids became the leading compounds with chemotherapeutic index > 8 and were chosen for further research.


 
DOI
http://doi.org/10.25135/acg.oc.66.19.07.1352
Keywords
synthesis triterpenoids oleanane ursane Chlamydia trachomatis
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© 2019 ACG Publications. All rights reserved.
Original Article

A Calix[4]arene-tren mdified electrode for determination of Lead ions in aqueous solution

Org. Commun. (2019) 12:3 ; 160 - 168
by M. Baris Kocer , Zehra Ozden Erdogan , Mehmet Oguz , Semahat Kucukkolbasi and Mustafa Yilmaz

In this study, a simple and sensitive electrochemical sensor based on Calix[4]arene-tren (Calix-tren)  modified glassy carbon (GC) electrode was developed for the determination of Pb (II) ions. Electrochemical behavior of Calix-tren modified electrodes were investigated by using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The results indicate that Calix-tren modified GC electrode provides good electron transmission pathway than bare GC electrode. The amount of Pb (II) was determined by differential pulse anodic stripping voltammetric analysis as a sensitive detection technique. The experimental parameters such as pH, deposition time and deposition potential were optimized.  The optimum pH value was selected as 7.0. The effect of deposition potential and deposition time on the peak current was tested and the optimum values were chosen as -1.2 V and 120 s, respectively. Under the optimal conditions, the working range of the developed sensor was determined as 0.48-2.31 µM, limit of detection (LOD) was 0.11 µM and the RSD obtained in the reproducibility study was 2.78 %. It was also found that the developed method could be used in the determination of Pb (II) ions in real samples with satisfactory results.

DOI
http://doi.org/10.25135/acg.oc.65.19.07.1330
Keywords
Calix[4]arene electrochemical sensor Pb (II)
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© 2019 ACG Publications. All rights reserved.
Original Article

Heterogeneous iota carrageenan-based palladium catalysts for organic synthesis

Org. Commun. (2019) 12:3 ; 149 - 159
by Adi Wolfson , Eric Pierschel , Tatiana Orzehovsky , Shira Nirenberg and Oshrat Levy-Ontman

Novel heterogeneous iota-carrageenan-based palladium catalysts were prepared and used in Suzuki cross coupling, Heck coupling and the transfer hydrogenation of olefins while using various substrates and solvents. In all of these reactions, heterogeneous systems based on xerogels or hydrogels were found to be active, and in certain cases, they yielded higher conversions than those of the homogeneous parent systems. Moreover, all the catalysts could be easily separated from the reaction mixtures and recycled without loss of activity.

DOI
http://doi.org/10.25135/acg.oc.61.19.07.1313
Keywords
Polysaccharides heterogeneous catalysis heterogenization Suzuki reaction Heck reaction transfer hydrogenation
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© 2019 ACG Publications. All rights reserved.
Original Article

A study of Minisci reaction by changing Fe2+ equivalency: Preparation of arylpyridinyl methanol

Org. Commun. (2019) 12:3 ; 143 - 148
by Bünyamin Özgeriş and Ferhan Tümer

We aimed the synthesis of carboxamide 8 and 10, however, beside the main product, one more species was detected in the reaction solution. The characterization of this side product showed that it was the other isomer of the main product. To establish reaction conditions for the synthesis of carboxamide derivatives, we have set up several experiments by changing the Fe2+ stoichiometry. When a molar equivalent Fe2+ was used, only two reaction products 8 and 10 were obtained. The increase in Fe2+ stoichiometry caused the formation of side product 9 and 11 even formation of reduced alcohol products (12-15) by Minisci reaction.

DOI
http://doi.org/10.25135/acg.oc.64.19.06.1309
Keywords
Minisci reaction nicotinamide isonicotinamide diarylmethanol
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© 2019 ACG Publications. All rights reserved.