Organic Communications

A scientific open acces journal in the field of synthetic organic chemistry and polymers
Editor-in-Chief: Hasan Seçen
Book Review and Review Article Editor: Turan Ozturk
Synthetic Polymer Section Editor: Mehmet S. Eroglu

LATEST ARTICLES

Original Article

A Calix[4]arene-tren mdified electrode for determination of Lead ions in aqueous solution

Org. Commun. (2019) in press ; 1 - 9
by M. Baris Kocer , Zehra Ozden Erdogan , Mehmet Oguz , Semahat Kucukkolbasi and Mustafa Yilmaz

In this study, a simple and sensitive electrochemical sensor based on Calix[4]arene-tren (Calix-tren)  modified glassy carbon (GC) electrode was developed for the determination of Pb (II) ions. Electrochemical behavior of Calix-tren modified electrodes were investigated by using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The results indicate that Calix-tren modified GC electrode provides good electron transmission pathway than bare GC electrode. The amount of Pb (II) was determined by differential pulse anodic stripping voltammetric analysis as a sensitive detection technique. The experimental parameters such as pH, deposition time and deposition potential were optimized.  The optimum pH value was selected as 7.0. The effect of deposition potential and deposition time on the peak current was tested and the optimum values were chosen as -1.2 V and 120 s, respectively. Under the optimal conditions, the working range of the developed sensor was determined as 0.48-2.31 µM, limit of detection (LOD) was 0.11 µM and the RSD obtained in the reproducibility study was 2.78 %. It was also found that the developed method could be used in the determination of Pb (II) ions in real samples with satisfactory results.

DOI
http://doi.org/10.25135/acg.oc.65.19.07.1330
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Calix[4]arene electrochemical sensor Pb (II)
Available online: August 25, 2019
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Letter to Editor

On the 150th anniversary of Markovnikov Rule

Org. Commun. (2019) in press ; 1 - 1
by Metin Balcı

In 1869, Vladimir Vasilyevich Markovnikov, a Russian organic chemist from the  University of Kazan formulated in his doctoral thesis the famous rule which is named after his name. According to this rule: When an unsymmetrically substituted unsaturated hydrocarbon reacts with hydrogen halides, the halide adds to the least hydrogenated carbon, that is to the one which experience more influence from the other neighbouring carbons. In other words: when an unsymmetrical alkene reacts with a hydrogen halide, the hydrogen adds to the carbon that has the greater number of hydrogen substituents, and the halogen to the carbon having the fewer number of hydrogen substituents” Markovnikov’s rule predicted the regioselectivity of electrophilic addition reactions of alkenes.

DOI
http://doi.org/10.25135/acg.oc.60.19.07.1358
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Markovnikov Rule Vladimir Vasilyevich Markovnikov
Available online: August 23, 2019
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Short Communication

An unprecedented synthesis of some novel 3,4-fused pyrazolidinone-γ-lactam bicyclic moieties from 2,3-dioxo-4-carboxy-5-(subtituted)pyrrolidines

Org. Commun. (2019) in press ; 1 - 11
by Fatin Nur Ain Abdul Rashid , Mohd Fazli Mohammat , Zurina Shaameri and Ahmad Sazali Hamzah

A new pathway for the synthesis of novel 3,4-fused pyrazolidinone-γ-lactam (4) starting from 2,3-dioxo-4-carboxy-5-(substituted)pyrrolidines (1) was developed. The key synthetic strategy involved hydrazonation of the precursor 1 followed by subsequent reduction reaction of the enamino ester 2 and intramolecular cyclization reaction to furnish the unprecedented 3,4-fused pyrazolidinone-γ- lactam (4) in reasonable yield. The structures of all synthesized compounds were confirmed by spectroscopic methods and chemical transformation.

DOI
http://doi.org/10.25135/acg.oc.62.19.07.1323
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Pyrazolidinone-γ-lactam Pyrazolidinone Pyrrolidinone Bicyclic γ-lactam
Available online: August 23, 2019
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Original Article

A study of Minisci reaction by changing Fe2+ equivalency: Preparation of arylpyridinyl methanol

Org. Commun. (2019) in press ; 1 - 6
by Bünyamin Özgeriş and Ferhan Tümer

We aimed the synthesis of carboxamide 8 and 10, however, beside the main product, one more species was detected in the reaction solution. The characterization of this side product showed that it was the other isomer of the main product. To establish reaction conditions for the synthesis of carboxamide derivatives, we have set up several experiments by changing the Fe2+ stoichiometry. When a molar equivalent Fe2+ was used, only two reaction products 8 and 10 were obtained. The increase in Fe2+ stoichiometry caused the formation of side product 9 and 11 even formation of reduced alcohol products (12-15) by Minisci reaction.

DOI
http://doi.org/10.25135/acg.oc.64.19.06.1309
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Minisci reaction nicotinamide isonicotinamide diarylmethanol
Available online: August 19, 2019
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