A scientific open access journal in the field of synthetic organic chemistry and polymers
Organic CommunicationsA scientific open access journal in the field of synthetic organic chemistry and polymers
Iodine-catalyzed addition of 2-mercaptoethanol to chalcone derivatives: Synthesis of the novel β-mercapto carbonyl compounds
In this study, a series of novel β-mercapto carbonyl derivatives (3-(2-hydroxyethylthio)-1,3- diarylpropan-1-one) (5a-i) were prepared by addition of 2-mercaptoethanol (4) to chalcones (3a-i) in the presence of catalytic amount of iodine (10 mol %) in CH2Cl2.Keywords Chalcone 2-mercaptoethanol iodine Thia-michael addition β-mercapto carbonyl. DETAILS PDF OF ARTICLE © 2012 ACG Publications. All rights reserved.
Synthesis of chalcone-containing zinc and cobalt metallophthalocyanines; investigation of their photochemical, DPPH radical scavenging and metal chelating characters
In this study, two new phthalocyanines (M = Zn and Co) were synthesized using the (E)-4-(4-(3-(4-(benzyloxy)phenyl)acryloyl)phenoxy)phthalonitrile (3) as ligand prepared from the chemical reaction of 4-nitrophthalonitrile with (E)-3-(4-(benzyloxy)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one (2). All compounds were characterized using by 1H-NMR, 13C-NMR, UV–Vis, FT-IR, and MALDI-TOF mass spectra. Singlet oxygen quantum yields of the synthesized compounds, aggregates in different solutions, metal chelating and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging properties were reported.
DOI http://doi.org/10.25135/acg.oc.80.20.05.1639 Keywords Phthalocyanines photochemical studies singlet oxygen quantum yields metal chelating DPPH radical scavenging DETAILS PDF OF ARTICLE © 2020 ACG Publications. All rights reserved.
Efficient synthesis and characterization of novel isoxazole derivatives including dihdyropyrazole and methanoisoindole moieties
Isoxazole and pyrazole derivatives have a wide range of biological activity and they are of great interest to medicinal chemist. In this study, the synthesis and characterization of a series of novel hybrid molecules containing pyrazole and isoxazole rings ((3aS,4S,4aR,7aS,8S,8aS)-6-(4-(1-acetyl-5-(4-(aryl/heteroaryl))-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-3-methyl-4,4a,8,8a-tetrahydro-3aH-4,8-methanoisoxazo-lo [4,5-f] isoindole-5,7(6H,7aH)-dione derivatives) were reported.DOI http://doi.org/10.25135/acg.oc.79.20.06.1668 Keywords Isoxazole synthesis characterization NMR DETAILS PDF OF ARTICLE © 2020 ACG Publications. All rights reserved.
N-Substituted aziridine 2-phosphonic acids and their antibacterial activities
N-substituted aziridine diethyl phosphonates were synthesized easily in two steps starting from vinyl phosphonate or acetyl phosphonate. The controlled mono hydrolysis without opening the aziridine ring under mild reaction conditions was achieved by alkaline solution of LiOH. The corresponding phosphonic acid lithium salt was desalted by the use of Amberlite IRC-50H+ acting as an efficient and recyclable weakly acidic cation exchange promoter. Antimicrobial activity of the synthesized compounds was tested against E. coli ATCC 25922, Staphylococcus aureus (MRSA), Klebsiella pneumoniae NRLL B-4420, Acetobacter baumanii (wild type), Pseudomonas aeroginosa (ATCC 27853) and Enterobacter aerogenes NRLL B-3567. In general, all the compounds showed moderate antibacterial activity.DOI http://doi.org/10.25135/acg.oc.77.20.03.1594 Keywords Aziridine-2-phosphonic acids atibacterial activity hydrolytic cleavage ion-exchange DETAILS PDF OF ARTICLE © 2020 ACG Publications. All rights reserved.