Organic Communications

A scientific open access journal in the field of synthetic organic chemistry and polymers
Editor-in-Chief: Hasan Seçen
Book Review and Review Article Editor: Turan Ozturk
Synthetic Polymer Section Editor: Mehmet S. Eroglu

LATEST ARTICLES

Short Communication

One-step transformation of a fluoro-based polymer into a superhydrophobic polymer composites

Org. Commun. (2019) 12:4 ; 222 - 226
by Mehtap Evci and Tuncer Caykara

We describe the formation of superhydrophobic surfaces by controlling the surface roughness using some simple processing methods, such as annealing at 120 °C, freeze-drying at -40 °C and composite film preparation. The root-mean-square (rms) roughness and the water contact angle values of untreated poly(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12-heneicosaffluorododecyl acrylate) (PHFDA) film prepared on silicon substrate using spin-coating technique were about 1.35 nm and  θA/θR = 125o/103o , respectively. On the other hand, the annealed film at 120 °C and the freeze-dried film at -40 °C with only a small increase in the rms roughness and the water contact angle values were 2.05 nm and θA/θR = 126o/111o , and 2.28 nm and θA/θR = 130o/123o, respectively. However, these values for the composite film composed of PHFDA and active carbon were 2.54 nm and θA/θR = 165o/164o, respectively. This method can be applied to various surfaces as long as the composites composed of nanoparticles and polymeric materials do not cause any aggregation in spin-coating.

DOI
http://doi.org/10.25135/acg.oc.68.19.09.1403
Keywords
Superhydrophobic surfaces surface roughness composite film active carbon spin-coating
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© 2019 ACG Publications. All rights reserved.
Short Communication

Oxidation of some benzyl substituted fused quinazoline derivatives

Org. Commun. (2019) 12:4 ; 217 - 221
by Dmytro Kravtsov

In this study, some benzoyl substituted fused quinazolines derivatives 4a-d were synthesized using Fieser’s reagent. Also this work reports about two non-specific products 5a and 6 of the reaction which were isolated from the reaction mixture. Based on the experimental data the potential oxidation mechanism of ketone 4a by chromium trioxide was described. The synthesized compounds were characterized by 1H, 13C, 19F NMR and LC-MS data.

DOI
http://doi.org/10.25135/acg.oc.70.19.11.1468
Keywords
oxidation fused quinazolines derivatives Fieser’s reagent benzyl to benzoyl mechanism
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© 2019 ACG Publications. All rights reserved.
Short Communication

Microvawe assisted synthesis of N-(methyl and methoxy) benzylidene-4-fluoroaniline derivatives and their carbonic anhydrase I and II inhibition properties

Org. Commun. (2019) 12:4 ; 210 - 216
by Hülya Çelik and Müslüm Kuzu

IIn this study, some Schiff base derivatives (6a-f) were synthesized using a microwave method. The synthesized compounds were characterized by 1D, 2D NMR and mass spectral data. Their inhibitory effects were studied on carbonic anhydrase isozymes (hCA I and II), purified from human erythrocyte cells by Sepharose-4B-L-tyrosine-sulfanilamide affinity chromatography and the compounds N-3-Methylbenzylidene-4-fluoroaniline (6b), N-4-Methylbenzylidene-4-fluoroaniline (6c), N-2-Methoxybenzylidene-4-fluoroaniline (6d)  showed moderate activity on hCAII in the range of IC50 values.

DOI
http://doi.org/10.25135/acg.oc.66.19.07.1327
Keywords
Schiff base carbonic anhydrase N-benzylideneaniline NMR HRMS
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© 2019 ACG Publications. All rights reserved.
Communication

Synthesis and cholinesterase inhibitory activity studies of some piperidinone derivatives

Org. Commun. (2019) 12:4 ; 202 - 209
by Sulunay Parlar

AA series of a,β-unsaturated carbonyl based piperidinone derivatives were synthesized and evaluated for their abilities to inhibit AChE and BuChE. All compounds exhibited AChE and BuChE inhibitory activity in different ratios. Among the series, compound 1d, (1-benzyl-3,5-bis(4-nitrobenzylidene)piperidine-4-one), was found to be the most potent derivative against AChE (IC50= 12.55 µM) and compound 1g, (1-benzyl-3,5-bis(4-chlorobenzylidene)piperidine-4-one) showed the best anti-BuChE activity (IC50= 17.28 µM). The derivatives exhibited selectivity on AChE enzyme with respect to BuChE. Only compound 1g, bearing chlorine substituents, demonstrated as a dual inhibitor of cholinesterases. Taken together, these results indicated that a,β-unsaturated carbonyl based piperidinone scaffold might be a promising drug candidate for further anti-AD drug development.

DOI
http://doi.org/10.25135/acg.oc.69.19.09.1399
Keywords
Acetylcholinesterase inhibitors Butyrylcholinesterase inhibitors Piperidinone Alzheimer’s disease
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© 2019 ACG Publications. All rights reserved.