Organic Communications Articles
Articles In Press
Articles In Press
1) Synthesis of (E)-10-hydroxy-2-decenoic acid ethyl ester via a one-pot tandem oxidation-Wittig process
The synthesis of (E)-10-hydroxy-2-decenoic acid ethyl ester (10H2DA-EE) (3) was achieved via a one-pot, tandem oxidation-Wittig process from commercially available 1,8-octanediol (1), Wittig reagent (Ph3P=CHCO2Et) (2) and activated MnO2. Subsequent hydrolysis with sodium hydroxide gave (E)-10-hydroxy-2-decenoic acid (10H2DA) (4).DOI http://doi.org/10.25135/acg.oc.48.18.06.106 (DOI number will be activated after the manuscript has been available in an issue.) Keywords One-pot tandem oxidation-Wittig process (E)-10-hydroxy-2-decenoic acid ethyl ester (E)-10-hydroxy-2decenoic Available online: September 12, 2018 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
2) Synthesis and anticancer (MCF-7, PC-3) activities of new 2-hydroxy-2,2-bis(4-substitutedphenyl)-N'-[(1E)-(3/4- substitutedphenyl)methylene]-acetohydrazides
A series of five –CH3, -NO2, -OCH3 and -Cl substituted 2-hydroxy-2,2-bis(4-phenyl)-N'-[(1E)-(3/4-phenyl)methylene]acetohydrazide (1a-1e) was synthesized by the reaction of 2-hydroxy-2,2-diphenylacetohydrazide with substituted aromatic aldehydes to give intermediate Schiff bases. Structures of the synthesized compounds were characterized using NMR (1D; 1H, 13C/APT and 2D 1H-1H COSY, and NOESY), FT-IR, UV, LC-MS/MS spectral data and elemental analysis. The geometry of compounds 1a-1e were determined to be “E” by NOESY. All the tested compounds showed cytotoxic activity on MCF-7 and PC-3 cell line at highest experimental concentration (100 µM). Compounds 1b (18.24 ± 7.62 µM) and 1e (7.62 ± 1.85 µM) have strong anti-proliferative activity on MCF-7 cell line, while compound 1b (45.81 ± 1.10 µM) has the strongest activity on PC-3 cell line.DOI http://doi.org/10.25135/acg.oc.47.18.06.107 (DOI number will be activated after the manuscript has been available in an issue.) Keywords 2-Hydroxy-2 2-diphenylacetic acid acetohydrazide derivatives MCF-7 PC-3. Available online: September 04, 2018 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
3) Practical synthesis and electronic study of non-spiro and spiropyrano[2,3-c]pyrazole-3-carboxylate derivatives via uncatalyzed domino one-pot, four-component reactions
A practical and efficient synthesis of non-spiro and spiropyrano[2,3-c]pyrazole-3-carboxylate derivatives was developed. The synthesis was achieved via a domino one-pot, four-component reaction of diethyl oxaloacetate, hydrazine, aldehyde and malanonitrile in refluxing acidic ethanolic solution under non-catalytic system. This method is rapid, simple and provides products in good yields and can be accessed via different classes of carbonyls, malanonitriles and hydrazine derivatives. Mechanistic study envisaged that this domino four-component reaction proceeds via sequential reactions of pyrazolone formation, Michael reaction and Thorpe-Ziegler cyclization reaction. Strong electronic effects of Knoevenagel and pyrozolone product contribute significantly towards successful cyclization of the title compounds.DOI http://doi.org/10.25135/acg.oc.46.18.05.104 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Pyrano[2 3-c]pyrazole-3-carboxylate diethyloxaloacetate Michael reaction Available online: September 04, 2018 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.