Journal of Chemical Metrology
A scientific open access journal in the field of analytical chemistry and accreditation
Journal of Chemical MetrologyA scientific open access journal in the field of analytical chemistry and accreditation
Determination of simethicone in different drug formulations by gravimetry and comparison with the FTIR method
Fourier transform infrared (FTIR) spectroscopy was mostly used in both pharmacopeia and literature studies to determine the assay of simethicone (SMT) in pharmaceuticals. It should be noted that HPLC is used less frequently. As an alternative to the mentioned methods a new, simple, fast, easy-to-apply and very cheap gravimetric method was developed and validated according to ICH guidance entitled Q2B Validation of Analytical Procedures: Methodology for the quantification analysis of simethicone in different pharmaceutical forms. For the simethicone suspension product provided to alleviate too much gas in the gastrointestinal tract, the simethicone amount was determined both by the validated gravimetric method and by the FTIR method defined in the USP and BP monographs, and the results were within the acceptance criteria. It is emphasized that there is no significant difference between the results of gravimetric and FTIR methods according to the calculated F- and t-test results.DOI http://doi.org/10.25135/jcm.44.20.07.1701 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Simethicone gravimetry F- and t-test method validation assay Available online: August 31, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
Assessment of the relationship between some physico-chemical properties of soil and soil algae in micro basin scale in Kocaeli
In this study, it was aimed to determine the relationship between soil algae and physico-chemical structure of soil. Algae composition and some soil quality parameters from 12 sampling stations were investigated between March 2019 and May 2019 in Kocaeli. Physico-chemical properties that reflect soil nutrient content and fertility status (pH, conductivity, salinity, CaCO3, organic matter, saturation, P2O5 and K2O) were determined using standard physicochemical techniques. Average in soil parameters were determined as pH: 8.06, conductivity: 5.79 µmhos / cm, salinity: 0.22 ‰, CaCO3: 9.98%, organic matter: 1.70%, saturation: 59.55%, P2O5: 3.16 kg / da, K2O: 93.92 kg / da. Algal flora of Kocaeli province was a total of 30 taxa, 14 taxa of Bacillariophyta, 3 taxa of Chlorophyta, 1 taxa of Charophyta and 12 taxa of Cyanobacteria were identified. The determined as the Chroococcus cohaerens, Limnococcus limneticus, Phormidium nigroviride, Oscillatoria limosa, Gomphonema olivaceum, Hantzschia amphioxys and Nitzschia brevissima most dominant taxa. These taxa have been identified in stations with high industrial activity. Bacillariophyta taxa were found in all months due to their ecological tolerance, while other species belong to spring. In this study, the species diversity were found similar in research stations.
DOI http://doi.org/10.25135/jcm.43.2005.1652 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Soil epipelic algae ecology micro basin physico-chemical parameters Available online: July 28, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
Impact of test conditions on the bacterial bioassay in the presence of TiO2 nanoparticles
To assess the fate and behavior of engineered nanoparticles in the aquatic environment, it is crucial to conduct appropriate bacterial bioassay procedure. However, test conditions of bacterial bioassay are limitedly investigated; especially in the field of environmental media chemistry or aging of nanoparticles which interfere the procedure. For this purpose, TiO2 nanoparticles were treated with different test conditions by keeping them in 1% and 100% seawater for one day and 20 days. The bacterial bioassay of treated nanoparticles towards gram-negative (Pseudomonas aeruginosa) and gram-positive (Staphylococcus aureus) bacteria were examined, as well as the mechanism by biochemical responses of bacteria and physicochemical properties of TiO2 nanoparticles. The viability response of tested bacteria reduced remarkably in seawater concentration, while treatment (aging) duration of tested nanoparticles slightly affected the viability response of tested bacteria. Moreover, key events which affected the bioassay response were changed with the treatment duration and media concentration. The results also showed that aging duration and concentration of the media influenced the main physicochemical properties due to the alterations in surface from aging media compared to unaged ones.DOI http://doi.org/10.25135/jcm.42.20.05.1648 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Nanoparticles bacteria bioassay interference nanometrology surface analysis ecotoxocology Available online: June 15, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.