Records of Natural Products
A scientific open access journal in the field of natural products.
Records of Natural ProductsA scientific open access journal in the field of natural products.
Salvianolic Acid B Attenuated Ischemia/Reperfusion-Induced Brain Injury in Mice by Inhibiting Reactive Oxygen Species-Mediated Inflammation
Salvianolic acid B (SAB) is one of main components of the dried roots and rhizomes of Salvia miltiorrhiza Bunge (RSM), which is widely used as a medicinal herb in East-Asia. According to traditional Korean medicine, RSM promotes blood flow, and thus, we investigated the effects of administering SAB after ischemia/reperfusion (I/R)-induced brain injury in a mouse model. I/R-induced brain injury was induced by middle cerebral artery occlusion (MCAO) for 2 h. SAB was orally administered to mice twice after 3 and 6 h of occlusion at 5, 15, or 45 mg/kg body weight. Administration of SAB at 45 mg/kg significantly reduced infarct volumes and edema indices and suppressed interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), and reactive oxygen species (ROS) levels in brain ipsilateral hemispheres. SAB also down-regulated Mn-SOD protein expression in affected brain tissues after I/R-induced brain injury. Our results indicate the neuro-protective effects of salvianolic acid B are due to its anti-inflammatory effect mediated by intra-cellular superoxide scavenging..DOI http://doi.org/10.25135/rnp.184.20.03.1573 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Salvianolic acid B Salvia miltiorrhiza ischemia/reperfusion injuryi nflammationb rain edema Available online: May 27, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
A New Diarylbenzophenone from Selaginella tamariscina
A new diarylbenzophenone, namely selagibenzophenone C (1), along with 1,3-di-p-hydroxyphenyl-4-penten-1-one, (2) and unciflavone E (3) were isolated from Selaginella tamariscina. Their structures were elucidated on the basis of spectroscopic and mass spectrometric analyses, including 1D-, 2D-NMR and HRESIMS. Compound 1 represents the first example of naturally occurring diarylbenzophenone. Compound 2 was firstly isolated from the genus of Selaginella.DOI http://doi.org/10.25135/rnp.182.20.03.1586 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Selaginella Selaginella tamariscina diarylbenzophenone selagibenzophenone C norlignan Available online: May 09, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
Two New Bibenzyl Compounds from Dendrobium lindleyi
Two new bibenzyl compounds 4,4',5-trihydroxy-3,3',α-trimethoxybibenzyl (1) and 4,5-dihydroxy-3, 3',4',α-tetramethoxybibenzyl (2), along with seven known compounds (3–9), were isolated from the methanol extract of the whole parts of Dendrobium lindleyi. The chemical structures were established on the basis of spectroscopic analysis including one and two-dimensional NMR spectroscopy and comparison with previously reported data.DOI http://doi.org/10.25135/rnp.181.20.02.1557 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Orchidaceae Dendrobium lindleyi Bibenzyl compound Available online: May 09, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
Chemical Constituents of the Seeds of Pharbitis purpurea and Laxative Effect of Methyl Caffeate on Rats
The chemical constituents of the seeds of Pharbitis purpurea belonging to the Convolvulaceae family were studied. The anti-tumor activities of all isolated compounds on A549 and HepG2 tumor cell lines and effect of methyl caffeate (8) on intestinal excretion in rats were also studied. Fourteen compounds were isolated from the seeds of P. purpurea by column chromatography using silica gel, ODS, Sephadex LH-20 and HPLC. Their structures were determined by 1D and 2D NMR and HRMS. They were identified as (2S,3S)-5-[(1E)-2-carboxyethenyl]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-3-benzofurancarboxylic acid dimethyl ester (1), 8-epiblechnic acid (2), dimethyl (1R,2S)-6,7-dihydroxy-l-(3,4-dihydroxy)-phenyl-1,2-dihydronaphthalene-2,3-dicarboxylate (3), dimethyl 6,9,10-trihydroxybenzo[kl]xanthene-1,2-dicarboxylate (4), syringaresinol-4’-O-β-D-glucopyranoside (5), (+)-syringaresinol (6), (+)-pinoresinol (7), methyl caffeate (8), ethyl caffeate (9), osmanthuside J (10), methyl 6β,7β,16β,17-tetrahydroxy ent-kauran-18-oate (11), β-sitosterol (12), 1-O-linoleoyl-glycol (13) and 1-O-linoleoyl-glycerol (14). Compounds 1 and 3 are new natural products. 4 is reported from the family Convolvulaceae for the first time and 8, 10 and 11 from P. purpurea for the first time. Methyl caffeate (8), 10 and 30 mg/kg, significantly promote intestinal peristalsis in rats. Methyl caffeate (8) has no acute toxicity to rats at 5000 mg/kg.DOI http://doi.org/10.25135/rnp.220.127.116.118 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Pharbitis purpurea chemical constituents promoting intestinal peristalsis methyl caffeate Available online: May 09, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.