Records of Natural Products

A scientific open acces journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Honorary Editor: Ayhan Ulubelen
Co-Editor-in-Chief: Ahmet C Gören

LATEST ARTICLES

Short Report

Glutinosine A: A New Morphinandienone Alkaloid from Litsea glutinosa

Rec. Nat. Prod. (2018) in press ; 1 - 4
by Yubin Ji, Chenxu Wang, Yuchen Zhang, Caiyun Zhang, Di Cui and Xiaopo Zhang
Abstract

A new morphinandienone alkaloid, named glutinosine A was isolated from the root barks of Litsea glutinosa. The new structure was determined by various spectroscopic techniques including 1D (1H-, 13C-NMR), 2D-NMR (HMBC, HSQC, COSY and ROESY) and high resolution electrospray ionization mass spectrometry (HR-ESI-MS). The effects of the new compound on glucose consumption in HepG2 cells were evaluated. Whereas, the result showed that this compound displayed no activity in stimulating glucose consumption.

DOI
http://doi.org/10.25135/rnp.92.18.06.306
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Litsea glutinosa Glutinosine A morphinandienone glucose consumption activities
Available online: November 12, 2018
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Short Report

Chemical composition of essential oils from leaves of six Piper species that grow in the Amazonia Biome, Brazil.

Rec. Nat. Prod. (2018) in press ; 1 - 9
by Claudio Augusto Gomes da Camara , Carolina Alves de Araujo , Marcilio Martins de Moraes , Geraldo José Nascimento de Vasconcelos , Charles Eugene Zartman and Marta Regina Silva Pereira
Abstract

Essential oils from the leaves of Piper japurense, P. coariense, P. auriculifolium, P. curtistilum, P. alatipetiolatum and P. brevesanum from the Amazon Forest (Brazil) were obtained through hydrodistillation. The chemical composition of the oils was determined using gas chromatography and mass spectrometry, which revealed the presence of 108 compounds representing 95.14 ± 0.35%, 95.64 ± 0.59%, 95.57 ± 0.48%, 92.05 ± 0.27%, 96.24 ± 1.04% and 91.31 ± 0.76% of the oils, respectively. The major components were α-eudesmol in the P. japurense (22.05 ± 0.15%) and P. coariense (27.33 ± 0.33%) oils, premnaspirodiene (32.26 ± 0.03%) in the P. auriculifolium oil, caryophyllene oxide (28.69 ± 0.17%) in the P. curtistilum oil, linalool (43.88 ± 0.50%) in the P. alatipetiolatum oil and β-elemene (12.75 ± 0.06%) in the P. brevesanum oil.

DOI
http://doi.org/10.25135/rnp.110.18.09.904
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Piper ssp Amazonia biome Essential oil Premnaspirodiene
Available online: November 12, 2018
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Original Article

A New Diterpene: Abietane Glycoside from the Roots of Isodon rugosus Wall Ex Benth.

Rec. Nat. Prod. (2018) in press ; 1 - 9
by Arif Ullah, Ghias Uddin, Mamoon Ur Rashid, Ismail Ismail, Nasruddin, Bina Shaheen Siddiqui, Zahoor Ullah, Muhammad Alamzeb
Abstract

The methanolic extract of the roots of Isodon rugosus were subjected to chromatographic separation, yielded two diterpenes: a new compound named rugosodon 1 and a known compound oridonin 2. The new compound 1 was elucidated as 1-O-α-D-glucopyranosyl-7α,13β-dihydroxyabieta-8(9)-en-11-one and the known compound 2 as 7α,20-epoxy-1α,6β,7,14-tetrahydroxy-kaur-16-en-15-one (oridonin), based on the chemical hydrolysis, physicochemical and spectroscopic data of IR, ESIMS, EIMS, 1D, and 2D NMR. The compounds 1-2 were subjected to bioassay studies of cytotoxicity and α-glucosidase inhibition potential. Rugosodon 1 showed significant potential of α-glucosidase inhibition with IC50 0.453 mg/mL, as compared to the standard acarbose (IC50 0.921 mg/mL). The compounds 1-2 failed to show any significant results for the cytotoxic screening against the three human cancer cell lines (NCI-H460, HeLa and MCF-7).

DOI
http://doi.org/10.25135/rnp.101.18.06.310
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Abietane diterpene glycoside Isodon rugosus rugosodon oridonin
Available online: November 11, 2018
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Original Article

Chemical Composition and Anti-Candida and Anti- Trypanosoma cruzi Activities of Essential Oils from the Rhizomes and Leaves of Brazilian Species of Renealmia L. fil.

Rec. Nat. Prod. (2018) in press ; 1 - 13
by Kathlyn V. Gevú, Helena R.P. Lima, Ilzenayde A. Neves, Érica O. Mello, Gabriel B. Taveira, Laís P. Carvalho, Mário G. Carvalho, Valdirene M. Gomes, Edésio J.T. Melo and Maura Da Cunha
Abstract

This work aimed to determine the chemical composition of essential oils from rhizomes and leaves of Renealmia chrysotricha Petersen, R. breviscapa Poepp. & Endl. and R. nicolaioides Loes., and to evaluate the biological activities of these oils on three Candida species and the parasite Trypanosoma cruzi. The rhizomes and leaves were collected in the Atlantic and Amazon rainforests. Essential oils were isolated and characterized by gas chromatography. Βeta-Caryophyllene was found to be the most predominant compound in the essential oils of rhizomes and leaves of R. breviscapa, and the rhizomes of R. nicolaioides, whereas (E)-nerolidol was the most abundant compound in the oils of leaves of R. nicolaioides. In R. chrysotricha, α-terpineol, coronarin-E and 1,8-cineole were found to be the most predominant compounds in the essential oils of rhizomes, whereas cis-3-hexenol was predominant in the leaves. The tested oils did not inhibit C. albicans growth at 1000 µg/mL, whereas leaf oils from R. chrysotricha and R. nicolaioides inhibited the growth of C. buinensis and C. tropicalis by about 50%. Essential oils from the rhizomes and leaves of R. chrysotricha exhibited efficient antiparasitic activity against Trypanosoma cruzi. Damage to T. cruzi epimastigotes was confirmed by LM and TEM.

DOI
http://doi.org/10.25135/rnp.105.18.08.125
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Zingiberaceae rhizomes leaves terpenoids anticandidal activity antiparasitic activity.
Available online: November 01, 2018
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