Records of Natural Products

A scientific open access journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Honorary Editor: Ayhan Ulubelen
Co-Editor-in-Chief: Ahmet C Gören

LATEST ARTICLES

Short Report

Antioxidants and α-Glucosidase Inhibitors from Lactuca serriola L.

Rec. Nat. Prod. (2020) in press ; 1 - 6
by Nouran H. Abdel Fatah , Yhiya Amen , Fatma M. Abdel Bar , Ahmed F. Halim and Hassan-Elrady A. Saad

Our main objective in the present study was to search for bioactive compounds of potential antidiabetic and antioxidant activities from the methanol extract of Lactuca serriola L. aerial parts for the prevention and treatment of diabetes. Phytochemical investigation allowed the isolation of 17 known compounds identified based on various spectroscopic techniques as lupeol (1), β-sitosterol (2), taraxast-20-ene-3β,20-diol (3), glycerol monopalmitate (4) (2S,3S,4R,2`R,14E)-2-(2`-hydroxytetracosanoylamino)-14-octadecene-1,3,4-triol (5), lactucopicrin (6), daucosterol (7), (E)-p-coumaric acid (8), 11β,13-dihydrolactucin (9), 4-hydroxybenzoic acid (10), protocatechuic acid (11), kaempferol (12), quercetin (13), lactuside A (14), luteolin-7-O-β-D glucoside (15), lactuside B (16) and cichorioside B (17). The antioxidant activity was evaluated using ABTS, DPPH radical scavenging assays and FRAP assay. The ethyl acetate fraction showed remarkable α-glucosidase inhibitory activity (IC50, 9.16±0.17 µg/mL) and antioxidant activity among the tested fractions. The in vitro α-glucosidase inhibitory assay is reported in this study for the first time for L. serriola L. The results strongly suggest that L. serriola L. can be used as a potential good natural remedy targeting oxidative stress-related diabetes mellitus.

DOI
http://doi.org/10.25135/rnp.189.2005.1647
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Asteraceae Lactuca serriola antioxidant α-glucosidase inhibitors
Available online: July 03, 2020
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Short Report

Aromatic Compounds from the Marine-Derived Fungus Aspergillus versicolor

Rec. Nat. Prod. (2020) in press ; 1 - 5
by Rong Yao , Shen Yao and Ailian Hua

Chemical investigation of the EtOAc extract of a marine-derived fungus Aspergillus versicolor SZW-5 led to the isolation of one new compound, named aspeverether A (1), and seven known compounds. The structures were determined by extensive analyses of spectroscopic data (1D and 2D NMR, and HRESIMS). Compounds 1 and 3 possessed an unusual 1,3-dimethoxy-2-vinylbenzene moiety, which is rarely found in nature. Compound 6 showed strong inhibitory effect toward a-glucosidase with an IC50 value of 71 mM, being more active than the positive acarbose (210 mM).

DOI
http://doi.org/10.25135/rnp.188.20.05.1664
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Aspergillus versicolor aspeverether A structure elucidation marine
Available online: June 28, 2020
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Original Article

Protective Effects of Origanum onites Essential Oil in the Methotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity

Rec. Nat. Prod. (2020) in press ; 1 - 10
by Asli Aykac , Eda Becer , Dilek Özbeyli , Göksel Şener and Kemal Hüsnü Can Başer

Methotrexate (MTX) is an effective cytotoxic agent which is used to treat malignancies and inflammatory diseases. Origanum onites (O. onites) is found throughout the Eastern Mediterranean region and has been used in traditional medicine. The essential oils (EOs) of O. onites rich in highly bioactive phytochemicals such as carvacrol (CVR) and has antiviral, antioxidant, anticancer and proapoptotic properties. The aim of this study was to investigate the protective effects of CVR and O. onites-EO treatment in MTX-induced hepatorenal toxic rats' liver and kidney tissues. The bcl-2/bax ratio, glutathione (GSH) level, malondialdehyde (MDA) level, and myeloperoxidase (MPO) activity of liver and kidney tissues were evaluated in the MTX-induced rat model. Results showed that the administration of CVR or O. onites-EO significantly increased bcl-2/bax expression and GSH levels as well as reduced MDA level and MPO activity in the kidney and liver tissues of MTX-induced rat model. In conclusion, our results suggest that O. onites-EO and CVR have protective effect in MTX-induced hepatorenal toxic rats' liver and kidney tissues by decreasing oxidative stress and apoptosis.

DOI
http://doi.org/10.25135/rnp.186.20.04.1631
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Methotrexate Origanum onites essential oil hepatorenal toxicity
Available online: June 16, 2020
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Original Article

The Leaf and the Gall Volatiles of Salvia fruticosa Miller from Turkey: Chemical Composition and Biological Activities

Rec. Nat. Prod. (2020) in press ; 1 - 15
by Sevda Süzgeç Selçuk , Temel Ozek , Gulmira Özek , Süleyman Yur , Fatih Göger , Bahar Gürdal , Gizem Gülsoy Toplan , Ali H. Meriçli and Kemal .H. Can Baser

In this study two different extraction techniques namely, conventional hydrodistillation (HD) and micro-steam distillation-solid-phase microextraction (MSD-SPME), were used to analyze the volatile constituents from the leaves and the galls of Salvia fruticosa Mill. by gas chromatography (GC-FID) and gas chromatography coupled to mass spectrometry (GC-MS). The oxygenated monoterpenes (62.4-69.3%) were found to be predominating compound group with 1,8-cineole and camphor as the main constituents in all the tested samples with the exception of the gall oil in which oxygenated sesquiterpenes (25.6%) and diterpenes (17.3%) were detected in high percentages. Qualitative differences of the volatiles obtained by HD and MSD-SPME techniques from the leaf and the galls are discussed. The resulting leaf essential oils were evaluated for their in vitro acetylcholinesterase (AChE) inhibition potential. In vitro DPPH scavenging, and Cupric Reducing Antioxidant Capacity (CUPRAC) assays were used to evaluate the leaf essential oils. AChE inhibition 41.2% and antioxidant 36.8% assays results showed moderate levels of activity. In this present study, to the best of our knowledge comparative leaf and gall volatiles of S. fruticosa was reported for first time.

DOI
http://doi.org/10.25135/rnp.185.20.03.1579
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Salvia fruticosa galls acetylcholinesterase antioxidant SPME GC-MS
Available online: June 15, 2020
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