Records of Natural Products

A scientific open access journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Honorary Editor: Ayhan Ulubelen
Co-Editor-in-Chief: Ahmet C Gören

LATEST ARTICLES

Short Report

Eudesmane Sesquiterpenoids from Salvia plebeia

Rec. Nat. Prod. (2021) in press ; 1 - 4
by Ying Lu and Yifang Chen

A new eudesmane sesquiterpene (1), named sapleudesone, together with four known analogs (25) were isolated from the aerial parts of Salvia plebeia. The structure of compound 1 was established by NMR and HRESIMS data, and the absolute configuration of 1 was determined by comparing the experimental ECD spectrum with the calculated ECD spectra. The known compounds were identified to be salplebeone A (2), linderolide I (3), chlorantene D (4), and chlomultin B (5) by comparing the NMR data and specific rotations with reported data. All five compounds were tested for the inhibitory effects against NO production in LPS-activated RAW 264.7 macrophages, As a result, compound 2 exhibited weak inhibitory effects with an IC50 value of 42.3  1.4 uM.

DOI
http://doi.org/10.25135/rnp.218.20.10.1856
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
eudesmane sesquiterpene Salvia plebeia; NO production inhibitory effects
Available online: January 01, 2021
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Original Article

Volatile Constituents of Cistanche tubulosa and Their Antioxidant and Antimicrobial Potentials

Rec. Nat. Prod. (2021) in press ; 1 - 11
by Arafa Musa , Khaled F. El-massry , Ahmed H. El-ghorab , Amr Farouk , Hazim M. Ali , Mohamed A. Abdelgawad , Ibrahim A. Naguib and Ehab M. Mostafa

Abstract: Abstract: The hydrodistilled volatile constituents of Cistanche tubulosa (commonly known as Desert Ginseng) have been chemically and biologically investigated. Based on the retention times and mass fragmentation of the obtained GC-MS chromatogram, 106 individual components which representing ≈ 99.29 % of the total volatile constituents have been identified. The major compounds (66.57% of the total composition) were identified as hexanal (15.98%), trans-sabinyl acetate (12.22%), allo-aromadendrene (9.30%), nonanoic acid (6.66%), 3Z- hexeny-2-methyl butanoate (6.09%), valeranone (5.25%), (E, E)-α-Farnesene (3.18%), a-pinene (3.06%), linalool isovalerate (3.03%) and a-humulene (1.8%). Estimation of the antioxidant activity of EO showed promising effect at 80 mg/mL concentration, it exerted 62.40, 863.29 and 62.72 % inhibition compared to TBHQ that showed 78.62, 77.56 and 79.23 % inhibition using DPPH, ABTS and β-carotene/Linoleic acid, respectively. The antioxidant activity was pronounced at 80 mg/mL than other concentrations. The volatile constituents showed inhibitory activity against gram positive bacteria ranged from 2.23 mg/100 mL ( for staphylococcus aureus ), and  15.68 mg/100 mL (for Bacillus cereus) compared to ciprofloxacin which showed inhibitory activity 0.185, and 0.182 mg/100 mL, respectively. Moreover, the MIC of volatiles towards gram negative bacteria are ranged from 18.35 (Escherichia coli) to 31.61 mg/100 mL (Klebsiella pneumonia) compared to ciprofloxacin with 0.184 to 0.188 mg/mL respectively. Additionally, the antifungal activity against candida albicans was rather promising (4.36 mg/mL).

DOI
http://doi.org/10.25135/rnp.220.20.11.1859
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Cistanche tubulosa volatile constituents antioxidant antimicrobial Orobanchaceae
Available online: January 01, 2021
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Review Article

Silybum marianum: not just Silymarin and Flavonolignans

Rec. Nat. Prod. (2021) in press ; 1 - 11
by Maria Giordano , Giovanni Luongo , Sergio Davinelli , Afef Ladhari , Giuseppina Rita Nappo and Maddalena Giordano

The use of Silybum marianum L. for therapeutic purposes has been known since ancient times. Its phytocomplex reduces transaminases and other biohumoral indices in the course of liver disease and also in hepato-renal syndrome. In particular, the flavonolignan component has shown properties that would partially explain the ability of the phytocomplex to induce a certain regeneration of liver cells, stimulate the cellular elimination of toxins and reduce the inflammatory component, present in fatty, alcoholic and hormonal therapies with steroids. S. marianum is also successfully used in the treatment of patients with symptomatic chronic hepatitis, with complete disappearance of clinical symptoms, such as asthenia, loss of appetite, severe meteorism, dyspepsia, and with normalization of transaminases. The same results can be obtained in patients undergoing heavy chemotherapy cycles. Modern herbal medicine uses it in decoction or infusion, however with some caution in patients suffering from hypertension, due to the presence of tyramine. In addition, the extracts of the roots have antioxidant, diuretic and febrifugal properties and those of the leaves have aperitif properties. It is therefore interesting to provide a picture of the different non-flavonolignanic components (terpenes, steroids and essential oils) of the plant and their properties, which have perhaps been wrongly neglected over the past few years.

DOI
http://doi.org/10.25135/rnp.18.17.06.108
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Silybum marianum silibinin terpenes steroids biological activity
Available online: December 26, 2020
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Short Report

Chemical Composition, and Evaluation of Antibacterial,Antibiofilm and Synergistic Effects with Conventional Antibiotics of Essential Oil from Mallotus repandus

Rec. Nat. Prod. (2021) in press ; 1 - 6
by Pengxiang Lai , Xin-Chen Zhang , Lin Zhu , Xin-Yu Li and Li-Chuan Liu

The essential oil (EO) of aerial parts of Mallotus repandus (Willd.) Muell. Arg. was extracted by hydrodistillation and characterized by GC/FID and GC/MS. Fifty-one compounds comprising 97.1% of the EO were identified, of which α-humulene  (18.7%), β-selinene (12.8%), aciphyllene (10.7%), (E)-caryophyllene (8.4%), α-copaene (5.5%), humulene epoxide II (4.9%) and caryophyllene oxide (4.3%) were the major compounds. The EO was evaluated for antibacterial properties using broth microdilution method and crystal-violet static biofilm formation assay. The M. repandus EO possessed a bactericidal effect against tested gram-positive bacteria strains (MIC = MBC: 0.05-0.10 mg/mL). Further, the EO showed the ability to inhibit the biofilm formation of Staphylococcus aureus. In addition, the potential synergistic effect was assessed by checkerboard method. Combination of the M. repandus EO with Streptomycin showed synergistic effects against the tested bacterial strains. This study demonstrates that M. repandus EO could be further explored as good alternative for potential pharmaceuticals.

DOI
http://doi.org/10.25135/rnp.217.20.10.1854
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Mallotus repandus (Willd.) Muell. Arg. essential oil antibacterial activity antibiofilm activity synergistic effects
Available online: December 20, 2020
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