Records of Natural Products

A scientific open acces journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Honorary Editor: Ayhan Ulubelen
Co-Editor-in-Chief: Ahmet C Gören

LATEST ARTICLES

Original Article

Cephalounei A, a New Cephalotaxus Alkaloid from the Powdered Stems of Cephalotaxus fortune Hook. f

Rec. Nat. Prod. (2019) in press ; 1 - 6
by Kangkang Mei , Guokai Wang , Heping Cai and Zhihong Luo

A new Cephalotaxus alkaloid, namely Cephalounei A (1), was isolated from the stems of Cephalotaxus fortune Hook. f. Their structures were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-, 2D-NMR and HRESIMS. The relative and absolute stereochemistry of 1 was determined by a combination of NOESY correlations and electronic circular dichroism (ECD) spectra, respectively. The cytotoxicity of all compounds were evaluated against five cancer cell lines.

DOI
http://doi.org/10.25135/rnp.19.02.1197
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Cephalotaxus alkaloid Cephalounei A ECD
Available online: May 23, 2019
DETAILS DOWNLOAD PDF
© ACG Publications. All rights reserved.
Original Article

Two New Cholestanol Glycosides from the Roots and Rhizomes of Smilacina henryi

Rec. Nat. Prod. (2019) in press ; 1 - 7
by Xin Zhang , Jing Sun , Shuo Zhang , Yafeng Yan , Rongxin Zhang , Xuanji Xue and Zengjun Guo

Abstract: Two new cholestanol glycosides (1 and 2) were obtained from the roots and rhizomes of Smilacina henryi. Their structures were determined as 5α-cholest-9(11)-ene-3β, 26-dihydroxy-16, 22-dione 3-O-β-D-glucopyranosyl-(1→2)-β-D-galactopyranoside (1), 5α-cholest-9(11)-ene-3β, 26-dihydroxy-16, 22-dione 3-O-β-D-glucopyranosyl-(1→2)- [β-D-glucopyranosyl-(1→3)]-β-D-galactopyranoside (2), by physicochemical properties and spectroscopic methods. In addition, the isolated glycosides were tested for their cytotoxic activity against human HepG2 tumor cells and compound 2 showed moderate activity with IC50 value of 59.32 μM.

DOI
http://doi.org/10.25135/rnp.19.03.1248
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Smilacina henryi cholestanol glycosides structure determination cytotoxicity
Available online: May 23, 2019
DETAILS DOWNLOAD PDF
© ACG Publications. All rights reserved.
Original Article

Cytotoxicity of Some Plants of the Asteraceae Family: Antiproliferative Activity of Psiadia punctulata Root Sesquiterpenes

Rec. Nat. Prod. (2019) in press ; 1 - 9
by Ammar Bader , Qasem Abdallah , Mohamed Abdelhady , Nunziatina De Tommasi , Nicola Malafronte , Usama Shaheen , Majdi Bkhaitan and Roberta Cotugno

According to the World Health Organization Cancer is the second leading cause of death globally. The methanol extracts of fourteen Middle-Eastern plants of the family Asteraceae were screened for antiproliferative activity on five cancer cell lines (A2780, MCF7, HeLa, RKO and Jurkat) by using MTT assay. Psiadia punctulata (DC.) Vatke was selected for isolation and elucidation of the bioactive constituents by 1D- and 2D-NMR, and MS analyses. Flow cytometry was used to evaluate cell cycle analysis, apoptotic hallmarks and reactive oxygen species. P. punctulata yielded a new sesquiterpene characterized as 7-hydroxy eudesman-3,5-dien-2-one (punctulin) (3) and three  known sesquiterpenes: 1, 2 and 4. The antiproliferative activity of all sesquiterpenes was evaluated in Jurkat (T-cell leukemia) and HeLa cancer cell lines. Compound 1 (1β-hydroxy-8-oxo-cyperone) has induced a significant growth inhibition in Jurkat and HeLa cells (IC50 =12 and 18µM respectively). Flow cytometry of compound 1 has elucidated the mechanism of action by showing its ability to induce cell cycle arrest in Jurkat cells mainly in G0/G1 and, less markedly, in G2/M. Compound 1 also expressed strong antioxidant activity by reducing the basal level of peroxides DHFDA-load in Jurkat cells. Compound 1 antioxidant activity may have contributed to the observed cell cycle arrest.

DOI
http://doi.org/10.25135/rnp.113.18.10.969
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Cytotoxic Activity Asteraceae Leukemia Cell cycle Sesquiterpenes
Available online: May 21, 2019
DETAILS DOWNLOAD PDF
© ACG Publications. All rights reserved.
Original Article

New Oxoprotoberberine and Aporphine Alkaloids from the Roots of Amoora cucullata with Their Antiproliferative Activites

Rec. Nat. Prod. (2019) in press ; 1 - 8
by Parinuch Chumkaew , Passakorn Teerapongpisan , Jaraslak Pechwang and Theera Srisawat

Two new oxoprotoberberine alkaloids, amocurine A and B (1 and 2), a new aporphine alkaloid, amocurine C (3), along with three known compounds (4-6) were isolated from the roots of Amoora cucullata. Their structures were determined by analysis of spectroscopic data. The isolated compounds were evaluated for their antiproliferative activity against three human cancer cell lines (KB, oral cavity; MCF-7, breast cancer; and NCI-H187, small cell lung cancer). Compounds 3 showed the most potent activities against KB and MCF-7 cell lines with IC50 values 3.5 and 4.2 mM, respectively.

DOI
http://doi.org/10.25135/rnp.128.19.02.1181
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Oxoprotoberberine Aporphine Antiproliferative activity Amoora cucullata
Available online: May 05, 2019
DETAILS DOWNLOAD PDF
© ACG Publications. All rights reserved.