Records of Natural Products
A scientific open access journal in the field of natural products.
Records of Natural ProductsA scientific open access journal in the field of natural products.
A New Angular Naphthopyrone from Crinoid Colobometra perspinosa
A chemical investigation was carried out on a crinoid Colobometra perspinosa collected from Hengchun Peninsula in the South China Sea, which led to the isolation of five angular naphthopyrones (1–5), including one new metabolite, 8-hydroxy-5,6,10-trimethoxy-2-pentyl-4H-naphtho[1,2-b]pyran-4-one (1). Their structures were assigned based on spectroscopic methods, including UV, HRESIMS, 1D- and 2D-NMR spectra. The anti-inflammatory activity of the isolated compounds was evaluated and compound 5 was found to inhibit the accumulation of the pro-inflammatory iNOS protein in LPS-stimulated RAW264.7 macrophages.DOI firstname.lastname@example.org (DOI number will be activated after the manuscript has been available in an issue.) Keywords angular naphthopyrone crinoid Colobometra perspinosa iNOS Available online: October 20, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
Antiradical Aromatic Constituents from Pleurotus eryngii
Six aromatic compounds including a new (Z)-ferulic acid ester (1) and a new syringic acid ester (2), as well as four known ferulic acid esters (3–6), were isolated from a well-known edible mushroom, Pleurotus eryngii. Structures of these aromatics were unambiguously characterized via spectroscopic methods especially MS and NMR techniques. All the isolates were assessed for their antiradical effect and NO production inhibitory activity in RAW264.7 macrophages, and compounds 1 and 3 displayed mild DPPH radical removing activity, with IC50 values of 25.0 and 21.6 mM, respectively.DOI http://doi.org/10.25135/rnp.205.20.08.1789 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Pleurotus eryngii aromatics ferulic acid ester syringic acid ester antiradical Available online: October 19, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
Benzodiazepine Derivatives from Marine-Derived Streptomyces cacaoi 14CM034
7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1). Structural elucidation of the compounds was based on FTIR, 1D- (1H and 13C NMR), 2D-NMR (COSY, HMBC and NOESY) and HR-MS analyses. Compounds 1 and 2 exhibited notable antimicrobial activity. The presence of PBD derivatives in S. cacaoi was first demonstrated with this study.DOI http://doi.org/10.25135/rnp.203.20.08.1766 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Marine actinobacterium Streptomyces cacaoi Benzodiazepine Antimicrobial activity Antibiotics Available online: October 19, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
Computational Study and Biological Evaluation of Isolated Saponins from the Fruits of Gleditsia aquatica and Gleditsia caspica
Phytochemical study of the ethanolic extract of the fruits of Gleditsia aquatica and Gleditsia caspica resulted in the isolation of the triterpene saponins; aquaticasaponin A (1), aquaticasaponin B (2), caspicaoside L (3) and caspicaoside M (4). Compound (1) showed good activity against methicillin resistant Staphylococcus aureus (MRSA) (IC50 =16.3 μg/mL) and Staphylococcus aureus (non-MRSA), (IC50 =12.2 μg/mL) and it expressed considerable cytotoxic activity against BT-549 (Human Ductal Carcinoma, Breast), KB (Human Epidermal Carcinoma, Oral) and SK-MEL (Human Malignant Melanoma) with IC50 values of 8.3, 10.0 and 3.3 μg/mL, respectively. Compounds (2) and (3) showed potent cytotoxicity against BT-549 with IC50 values of 5.3 and 7.3 μg/mL, and against SK-MEL with IC50 values of 4.3 and 3.1 μg/mL, respectively. Compound (4) showed good cytotoxicity against KB with IC50 value of 7.3 μg/mL. In consistent, the study of molecular determinates of cytotoxic activity of these new scaffolds showed close high docking scores to CD81 (Cluster of Differentiation 81) human antigen which could be of great importance for the development of new cytotoxic candidates. The structure identification of isolated metabolites was carried out using 1D and 2D NMR and mass spectra.DOI http://doi.org/10.25135/rnp.202.20.08.1764 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Triterpenoidal saponins cytotoxicity CD81 human antigen computational study MRSA Available online: October 18, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.