Records of Natural Products

A scientific open access journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Honorary Editor: Ayhan Ulubelen
Co-Editor-in-Chief: Ahmet C Gören

LATEST ARTICLES

Original Article

Essential Oils of Three Hypericum Species from Colombia: Chemical Composition, Insecticidal and Repellent Activity Against Sitophilus zeamais Motsch. (Coleoptera: Curculionidae)

Rec. Nat. Prod. (2020) in press ; 1 - 11
by William Ramiro Patiño Bayona , Erika Plazas , Jenifer Jhoana Bustos Cortes , Juliet Angélica Prieto Rodríguez and Oscar Javier Patiño Ladino

The maize weevil (Sitophilus zeamais) is one of the main insect responsible of significant losses in stored products,  and  to keep nutritional value of them to find  effective and safe solutions are very important. The Hypericum genus might be a potential source of new bio-insecticides due to the chemical composition of essential oils.  In this study, components of  essential oils of three Hypericum species were investigated for first time by Gas Chromatography-Mass Spectrometry (GC-MS) and, fumigant and contact toxicities as well as the repellent activity of essential oils of them were evaluated against S. zeamais adults. While the main components in H. mexicanum oil were determined as  n-nonane (53.08%) and α-pinene (25.28%), the major constituents  were determined as α-pinene (45.52%) and β-caryophyllene (13.59%) in the essential oil of H. myricariifolium. Chemical composition of  essential oil of H. juniperinum were found to be n-nonane (12.0%), α-pinene (8.25%), geranyl acetate (7.93%), and β-caryophyllene (13.60%). The results revealed that H. mexicanum and H. myricariifolium oils have fumigant toxicity (LC50 < 500 µL/L air) and a potential action as repellents (RP > 70% at 6.2–22.7 μL/L air) for the control of the pest.

DOI
http://doi.org/10.25135/rnp.192.20.05.1665
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Sitophilus zeamais essential oil repellent Hypericum mexicanum Hypericum myricariifolium Hypericum juniperinum
Available online: September 14, 2020
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Original Article

A New Cynaropicrin Derivative from Cynara Scolymus L.

Rec. Nat. Prod. (2020) in press ; 1 - 8
by Ghada Abbas , Amal Sallam , Fatma M. Abdel Bar , Mohamed Farid Lahloub and Ahmed Gohar

A new sesquiterpene lactone 1a along with other four known compounds 1b, 2, 3 and 4 were isolated from fresh leaves of Cynara scolymus L. using ordinary chromatographic techniques. The structures of the isolated compounds were determined via spectroscopic analysis.

DOI
http://doi.org/10.25135/rnp.198.20.07.1747
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Cynara scolymus sesquiterpene lactones dihydrocynaropicrin etrahydrocynaropicrin pinoresinol luteolin
Available online: September 08, 2020
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Original Article

Chemical Constituents of Tibetan Herbal Medicine Pulicaria insignis and Their in vitro Cytotoxic Activities

Rec. Nat. Prod. (2020) in press ; 1 - 12
by Xinzhu Wang , Peilei Hou , Yanbo Qu , Rizhen Huang , Yan Feng , Shifeng Zhao , Yelin Ding and Zhixin Liao

Abstract:  One new phenolic derivative, 1-(4',5'-dihydroxy-2'-methylphenyl)-pentane-1,4-dione (1), along with eighteen known compounds including eight sesquiterpenoids (29), one triterpenoid (10), one bisdpoxylignan (11), one coumarin (12),  and seven flavonoids (1319) were isolated from the dried inflorescence of Tibetan herbal medicine Pulicaria insignis. The structure of 1 was established by spectroscopic methods, including HRESIMS, IR, 1D, and 2D NMR. All isolates were assessed for the cytotoxic activities against MGC-803, T24, HepG2, and HeLa cell lines using the MTT assay. The results showed that compound 1 displayed moderate cytotoxicity against Hela and HepG2, and compounds 3, 4, 5, 6, and 13 exhibited potential cytotoxic activities against the four cell lines with IC50 values ranging from 3.05 to 14.37 μM. Notably, compound 5 exhibited significant anti-proliferative activities against HepG2 cell lines with the IC50 values of 3.05 ± 0.36 μM. Further bioactivity investigation showed that compound 5 could block HepG2 cells in the G1 phase of the cell cycle, thereby inhibiting the growth of HepG2 cells and inducing apoptosis in HepG2 cells.

DOI
http://doi.org/10.25135/rnp.193.20.06.1692
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Pulicaria insignis chemical constituent phenolic derivative cytotoxic activity sesquiterpenoid
Available online: August 24, 2020
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Original Article

Identification and Structural Characterization of Anti-Endoplasmic Reticulum Stress Compounds from Ageratum conyzoides (L.)

Rec. Nat. Prod. (2020) in press ; 1 - 9
by Tran Duy Binh , Ryo Kusunoki , Thanh Q. C. Nguyen , Ako Nakagami , Kenji Kanaori , Yen D. H. Nguyen , Tuan L. A. Pham , Cuong C. Nguyen , Le Van Vang and Kaeko Kamei

Ageratum conyzoides is an herbaceous plant widely used in traditional medicine against various diseases, and possesses anti-inflammatory, anti-ulcer, analgesic, and diuretic properties. However, its effects on endoplasmic reticulum (ER) stress, as observed in diseases such as diabetes, have not yet been characterized. In this study, using mouse pancreatic Beta-cells, we demonstrated that the ethanol extract of A. conyzoides effectively suppressed cell death induced by ER stress. Four polymethoxyflavones (PMFs) including (1) 5,6,7,3′,4′,5′- hexamethoxyflavone; (2) 5,6,7,8,3′,4′-hexamethoxyflavone (nobiletin); (3) 3′,4′-methylenedioxy-5′,5,6,7- tetramethoxyflavone; and (4) 5,6,7,8,5′-pentamethoxy-3′,4′-methylenedioxyflavone were isolated from the ethyl acetate fraction using reverse-phase chromatography. Their structures were elucidated using spectroscopic and mass-spectrometric analyses including 1D-, 2D-NMR, and HRESI-MS. All compounds were further evaluated for their ability to inhibit ER stress. Our results suggested that only compound 1 did not show an ability to rescue ER stress-induced cell death. Additionally, compound 2 as a nobiletin and its commercial product alleviated the tunicamycin-dependent chop mRNA expression induction. Notably, extremely low concentrations of both compounds exerted cytoprotective activity against tunicamycin-induced ER stress in pancreatic Beta-cells

DOI
http://doi.org/10.25135/rnp.194.20.06.1697
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Ageratum conyzoides anti-endoplasmic reticulum stress pancreatic-cells nobiletin
Available online: August 24, 2020
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