Records of Natural Products
A scientific open access journal in the field of natural products.
Records of Natural ProductsA scientific open access journal in the field of natural products.
A New Dopamine Derivative from Cotidius chinensis
A new dopamine derivative (1), along with three known analogues (2‒4), was isolated from the medical insect Cotidius chinensis. Their chemical structures were identified by spectral data including HR-ESI-MS, 1D and 2D NMR.DOI http://doi.org/10.25135/rnp.188.8.131.523 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Cotidius chinensis Aspongopus chinensis dopamine derivative medical insect cotidione A Available online: April 07, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
A New Labdane Diterpene from the Aerial Parts of Chloranthus serratus
A new labdane diterpene (1) and five known compounds (2-6) were isolated from the aerial parts of Chloranthus serratus. The gross structure of compound 1 was resolved by NMR and HRESIMS data. The absolute configuration of 1 was determined by comparing CD spectrum and specific rotations with those of the co-isolated known analogue 2. The known compounds were identified to be agathic acid (2), altechromone (3), chlorajapolide F (4), shizukanolide (5), and chloranthalactone E (6) by comparing the NMR data with those in the literature. ll compounds were evaluated for their inhibitions against NO production in LPS-activated RAW 264.7 macrophages, compounds 2 and 6 showed moderate inhibitions with IC50 values of 45.2 ± 1.2 and 35.3 ± 0.9 mM.DOI http://doi.org/10.25135/rnp.175.20.02.1559 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Chloranthus serratus labdane diterpene inhibitions NO production Available online: April 05, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
Structure, Absolute Configuration and Biological Evaluation of a New Labdane Diterpenoid from Jatropha podagrica
Jatrodagricaine A (1), a new labdane-type diterpenoid, together with three known derivatives (2−4) were isolated from the leaves of Jatropha podagrica. Their structures were elucidated by extensive spectroscopic methods. The absolute configuration of 1 was established by its biosynthetic pathway and comparison to known compound. All compounds were investigated for their anti-inflammatory and thioredoxin reductase (TrxR) inhibitory activities. Compound 1 showed potential inhibition in terms of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages with IC50 value of 40.6 ± 2.2 μM.DOI http://doi.org/10.25135/rnp.172.1912.1495 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Jatropha podagrica labdane diterpenoid anti-inflammatory activity thioredoxin reductase Available online: April 02, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
New Spectinabilin and Hexadienamide Derivatives from Streptomyces sp. S012
A new spectinabilin derivative (1) and hexadienamide (3), together with (-)-spectinabilin (2) and sarmentosamide (4), were isolated from Streptomyces sp. S012. Their structures were elucidated on the basis of spectroscopic analysis, including 1H, 13C NMR, 1H-1H COSY, HSQC, HMBC, NOESY and HRESIMS. Their antibacterial activity was also evaluated in this study.DOI http://doi.org/10.25135/rnp.184.108.40.2060 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Spectinabilin hexadienamide Streptomyces sp. S012 spectral data Available online: March 17, 2020 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.