Records of Natural Products

A scientific open access journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Honorary Editor: Ayhan Ulubelen
Co-Editor-in-Chief: Ahmet C Gören

LATEST ARTICLES

Original Article

Antimicrobial Effect and Antioxidant Activity of Triterpenes Isolated from Gymnema sylvestre R. Br.

Rec. Nat. Prod. (2020) in press ; 1 - 6
by Valeria Romanucci , Maria Giordano , Sergio Davinelli , Cinzia Di Marino , Afef Ladhari and Anna De Marco

Gymnema sylvestre is a commonly used herb in Ayurvedic medicine. The demand for its extracts in the commercial and pharmaceutical fields has been steadily increasing in recent years. Its extracts are used to treat various ailments as well as for their antimicrobial properties. This study has evaluated the antimicrobial effects of different G. sylvestre extracts and of eight triterpenes isolated from the most active extract on six bacterial poultry pathogens i.e. Bacillus subtilis, Enterococcus faecalis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Enterobacter aerogenes. In particular, it has been evaluated the minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) of all extracts and isolated triterpenes. Finally, the cytotoxicity activity of triterpenes was evaluated by MTT assay and their antioxidant activity in basal and oxidant conditions by DCFH-DA assay.

DOI
http://doi.org/10.25135/rnp.165.19.10.1448
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Gymnema sylvestre antimicrobial effects triterpenes gymnemic acids herbal drug DCFH-DA assay
Available online: January 13, 2020
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Original Article

Chemical Composition and Anticholinesterase Activity of the Essential Oil from the Ecuadorian Plant Salvia pichinchensis Benth

Rec. Nat. Prod. (2020) in press ; 1 - 10
by Melissa Salinas , Nicole Bec , James Calva , Jorge Ramirez , José Miguel Andrade , Christian Larroque , Giovanni Vidari and Chabaco Armijos

Salvia pichinchensis Benth was collected in the South of Ecuador and the essential oil (EO) was distilled from aerial parts and analyzed by GC-MS and GC-FID. The physical properties, chemical composition, and cholinesterase inhibitory activity were determined. Six major components, all sesquiterpenes, were identified: cis-cadina-1(6),4-diene (17.11%) (1),γ-curcumene (13.75%) (2), (E)-caryophyllene (12.58%) (3), (E,E)-α-farnesene (10.00%) (4), α-gurjunene (9.46%) (5) and allo-aromadendrene (6.96%) (6). The EO showed an interesting selective inhibitory activity against the enzyme butyrylcholinesterase (50.70 μg/mL) and only low inhibitory activity against acetylcholinesterase (117.60 μg/mL). The chemical composition and butyrylcholinesterase activity of the EO of S. pichinchensis Benth was reported for first time.

DOI
http://doi.org/10.25135/rnp.164.19.07.1342
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Salvia pichinchensis essential oil GC-MS analysis in vitro ChE inhibitory activity cis-cadina-1(6),4-diene
Available online: January 09, 2020
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Original Article

Novel Hopanoic Acid and Depside from the Lichen Dirinaria applanata

Rec. Nat. Prod. (2020) in press ; 1 - 8
by Nguyen Trong Tuan , Mai Van Hieu , Nguyen Quoc Chau Thanh , Huynh Van Loi , Huu Lai Nghia , Tran Thi Tuyet Hoa and Kanaori Kenji

From the extract of lichen Dirinaria applanata, two hopane derivatives including 1b-acetoxy-3b-hydroxy-21a-hopan-29-oic acid (1), hopane-3b, 6b, 21a-triol (2) and a depside namely 2-O¢-methylnordivaricatic acid (3) were isolated and identified by extensive analyzing 1D-NMR, 2D-NMR, HRESI-MS, and FT-IR. Notably, compound 1 and 3 were novel compounds while compound 2 was isolated from this lichen species for the first time.

DOI
http://doi.org/10.25135/rnp.161.19.10.1441
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Dirinaria applanata lichen hopan-29-oic acid depside
Available online: January 02, 2020
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Short Report

Two New Compounds from the Deep-Sea-Serived Fungus Aspergillus sp. YPGA8

Rec. Nat. Prod. (2020) in press ; 1 - 5
by Meng-Hua Pan , Zhi-Yong Tian , Hui Yang , Wei Xu , Chen Pan , Zhongbin Cheng and Qin Li

Chemical examination of a fraction of the EtOAc extract of a marine-derived fungus Aspergillus sp. YPGA8 resulted in the isolation of two new compounds, namely aspertriols A-B (1-2). Compounds 1-2 possess an identical 2,3,4-trihydroxybutoxy moiety, which is rarely found in natural products. Their structures were determined by extensive analyses of spectroscopic data (1D and 2D NMR, HRESIMS). The bioassay study revealed that compounds 1 and 2 were inactive toward a-glucosidase.

DOI
http://doi.org/10.25135/rnp.162.19.11.1487
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
marine-derived fungus Aspergillus sp. YPGA8 aspertriols A-B isolation structure identification
Available online: December 20, 2019
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© ACG Publications. All rights reserved.