Records of Natural Products
A scientific open acces journal in the field of natural products.
Records of Natural ProductsA scientific open acces journal in the field of natural products.
Cephalounei A, a New Cephalotaxus Alkaloid from the Powdered Stems of Cephalotaxus fortune Hook. f
A new Cephalotaxus alkaloid, namely Cephalounei A (1), was isolated from the stems of Cephalotaxus fortune Hook. f. Their structures were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-, 2D-NMR and HRESIMS. The relative and absolute stereochemistry of 1 was determined by a combination of NOESY correlations and electronic circular dichroism (ECD) spectra, respectively. The cytotoxicity of all compounds were evaluated against five cancer cell lines.DOI http://doi.org/10.25135/rnp.19.02.1197 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Cephalotaxus alkaloid Cephalounei A ECD Available online: May 23, 2019 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
Two New Cholestanol Glycosides from the Roots and Rhizomes of Smilacina henryi
Abstract: Two new cholestanol glycosides (1 and 2) were obtained from the roots and rhizomes of Smilacina henryi. Their structures were determined as 5α-cholest-9(11)-ene-3β, 26-dihydroxy-16, 22-dione 3-O-β-D-glucopyranosyl-(1→2)-β-D-galactopyranoside (1), 5α-cholest-9(11)-ene-3β, 26-dihydroxy-16, 22-dione 3-O-β-D-glucopyranosyl-(1→2)- [β-D-glucopyranosyl-(1→3)]-β-D-galactopyranoside (2), by physicochemical properties and spectroscopic methods. In addition, the isolated glycosides were tested for their cytotoxic activity against human HepG2 tumor cells and compound 2 showed moderate activity with IC50 value of 59.32 μM.DOI http://doi.org/10.25135/rnp.19.03.1248 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Smilacina henryi cholestanol glycosides structure determination cytotoxicity Available online: May 23, 2019 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
Cytotoxicity of Some Plants of the Asteraceae Family: Antiproliferative Activity of Psiadia punctulata Root Sesquiterpenes
According to the World Health Organization Cancer is the second leading cause of death globally. The methanol extracts of fourteen Middle-Eastern plants of the family Asteraceae were screened for antiproliferative activity on five cancer cell lines (A2780, MCF7, HeLa, RKO and Jurkat) by using MTT assay. Psiadia punctulata (DC.) Vatke was selected for isolation and elucidation of the bioactive constituents by 1D- and 2D-NMR, and MS analyses. Flow cytometry was used to evaluate cell cycle analysis, apoptotic hallmarks and reactive oxygen species. P. punctulata yielded a new sesquiterpene characterized as 7-hydroxy eudesman-3,5-dien-2-one (punctulin) (3) and three known sesquiterpenes: 1, 2 and 4. The antiproliferative activity of all sesquiterpenes was evaluated in Jurkat (T-cell leukemia) and HeLa cancer cell lines. Compound 1 (1β-hydroxy-8-oxo-cyperone) has induced a significant growth inhibition in Jurkat and HeLa cells (IC50 =12 and 18µM respectively). Flow cytometry of compound 1 has elucidated the mechanism of action by showing its ability to induce cell cycle arrest in Jurkat cells mainly in G0/G1 and, less markedly, in G2/M. Compound 1 also expressed strong antioxidant activity by reducing the basal level of peroxides DHFDA-load in Jurkat cells. Compound 1 antioxidant activity may have contributed to the observed cell cycle arrest.DOI http://doi.org/10.25135/rnp.188.8.131.529 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Cytotoxic Activity Asteraceae Leukemia Cell cycle Sesquiterpenes Available online: May 21, 2019 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.
New Oxoprotoberberine and Aporphine Alkaloids from the Roots of Amoora cucullata with Their Antiproliferative Activites
Two new oxoprotoberberine alkaloids, amocurine A and B (1 and 2), a new aporphine alkaloid, amocurine C (3), along with three known compounds (4-6) were isolated from the roots of Amoora cucullata. Their structures were determined by analysis of spectroscopic data. The isolated compounds were evaluated for their antiproliferative activity against three human cancer cell lines (KB, oral cavity; MCF-7, breast cancer; and NCI-H187, small cell lung cancer). Compounds 3 showed the most potent activities against KB and MCF-7 cell lines with IC50 values 3.5 and 4.2 mM, respectively.DOI http://doi.org/10.25135/rnp.128.19.02.1181 (DOI number will be activated after the manuscript has been available in an issue.) Keywords Oxoprotoberberine Aporphine Antiproliferative activity Amoora cucullata Available online: May 05, 2019 DETAILS DOWNLOAD PDF © ACG Publications. All rights reserved.