Records of Natural Products

A scientific open acces journal in the field of natural products.
Editor-in-Chief: Gülaçtı Topçu
Honorary Editor: Ayhan Ulubelen
Co-Editor-in-Chief: Ahmet C Gören

LATEST ARTICLES

Original Article

Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts

Rec. Nat. Prod. (2018) in press ; 1 - 11
by Belkıs Halfon, Özlem Çetin, Gamze Kökdil and Gülaçtı Topçu
Abstract

In this study the antioxidant and anticholinesterase activities of the crude ethanol extract, as well as the dichloromethane and water extracts obtained from partitioning of the crude ethanol extract, of the plant Salvia cassia Samuelss ex. Rech. Fil, were determined. The extracts were screened for their total phenolic and flavonoid contents. The dichloromethane extract, which showed higher inhibition of lipid peroxidation, higher metal chelating capacity and also a higher flavonoid content than the other extracts was analyzed for its constituents. GC-MS analysis resulted in the identification of a total of 30 long chain hydrocarbons. A series of b-amyrin fatty acid esters, a triterpene acid oleanolic acid, a diterpenoid manoyloxide, and two flavonoids apigenin 7, 4′-dimethyl ether and salvigenin were isolated by open column chromatography. Their structures were identified based on NMR and mass spectrometric techniques. The isolated compounds were also tested for their anticholinesterase activities. The triterpenoids as well as the water extract exhibited promising anticholinesterase activity.

DOI
http://doi.org/10.25135/rnp.99.18.05.291
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Salvia cassia antioxidant activity anticholinesterase activity fatty acid composition -amyrin fatty acid esters flavonoids.
Available online: October 16, 2018
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Short Report

Essential Oil Constituents from the Leaves of Anoectochilus setaceus, Codonopsis javanica and Aristolochia kwangsiensis from Vietnam

Rec. Nat. Prod. (2018) in press ; 1 - 6
by Tran M. Hoi, Do N. Dai, Chu T. T. Ha, Ha V. Anh and Isiaka A. Ogunwande
Abstract

There are very few reports on the phytochemistry of Anoectochilus setaceus Blume, Codonopsis javanica (Blume) Hook. f. and Aristolochia kwangsiensis Chun & F.C.How ex S.Yun Liang species in the literature. Here we present essential oil compositions of the three endemic plants from Vietnam. The analysis of the chemical constituents of the hydrodistilled essential oils was achieved by using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The essential oils of A. setaceus, C. javanica and A. kwangsiensis afforded very low oil yields: 0.12%, 0.31% and 0.10% (v/w), respectively, calculated on a dry weight basis. The result indicated that the major components of the leaf oil of A. setaceus consist mainly of α-cadinol (17.1%), (E,E)-farnesol (14.0%) and terpinen-4-ol (11.0%) while β-pinene (20.8%) and α-pinene (15.4%) were the main compounds identified in C. javanica. However, the significant compounds of A. kwangsiensis were sabinene (34.8%), β-caryophyllene (8.8%) and terpinen-4-ol (8.6%). To the best of our knowledge this is the first report on the essential oil compositions of these species.

DOI
http://doi.org/10.25135/rnp.103.18.08.124
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Anoectochilus setaceus Codonopsis javanica Aristolochia kwangsiensis essential oil terpenoids.
Available online: October 16, 2018
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© ACG Publications. All rights reserved.
Original Article

Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic Anhydrase I (hCA I) and II (hCA II)

Rec. Nat. Prod. (2018) in press ; 1 - 10
by Tuba Aydın, Bayram Yurtvermez, Murat Şentürk, Cavit Kazaz and Ahmet Çakır
Abstract

Tarragon or Dragon's-wort (Artemisia dracunculus L.) is widely used as spice and in traditional medicine in various regions of the world. Inhibitory effects of the n-hexane, dichloromethane, ethanol and methanol extracts of the leaves of tarragon on the human carbonic anhydrase (hCA) I and II enzymes were investigated. Dichloromethane extract exhibited the strongest activity with lowest IC50 value (0.020 and 0.031 μg/mL, respectively). The chromatographic studies on the dichloromethane extract of tarragon allowed the isolation of six known strong inhibitors of hCA isozymes as trans-anethole, stigmasterol, herniarin, (2E,4E)-N-isobutylundeca-2,4-dien-8,10-diynamide, (2E,4E)-1-(piperidin-1-yl)undeca-2,4-diene-8,10-diyn-1-one and 1-(4'-methoxyphenyl)-1,2,3-trihydroxypropane. The compound, 1-(4'-methoxyphenyl)-1,2,3-trihydroxypropane was isolated from tarragon for the first time in this study. Among the tested compounds, 1-(4'-methoxyphenyl)-1,2,3-trihydroxypropane showed the highest inhibitiory impact on both hCA isozymes. Also its IC50 values were found lower than positive control, acetazolamide.

DOI
http://doi.org/10.25135/rnp.102.18.07.329
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Artemisia dracunculus L. 1-(4'-methoxyphenyl)-1 2 3-trihydroxypropane enzyme inhibition hCA I hCA II.
Available online: October 14, 2018
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Original Article

Phytochemical Profiles and Antioxidant Activity of Salvia species from Southern Italy

Rec. Nat. Prod. (2018) in press ; 1 - 11
by Marzia Vergine, Francesca Nicolì, Carmine Negro, Andrea Luvisi, Eliana Nutricati, Rita Annunziata Accogli, Erika Sabella and Antonio Miceli
Abstract

The purpose of this research was to investigate phytochemical profiles and antioxidant activity in four Salvia species growing in Salento (Southern Italy). The hydrodistillation products obtained from the aerial parts of Salvia clandestina, Salvia fruticosa, Salvia officinalis and Salvia sclarea were characterized by GC–MS and 50 compounds were detected. With the exception of S. clandestina, that did not produce essential oils, the other species shared different amounts of monoterpenes oxygenated (camphor 2.13%-9.16%) and sesquiterpenes hydrocarbons (caryophyllene 4.65%-18.33%; humulene 1.87%-12.39%). The phenolic profiling, analyzed by HPLC ESI/MS-TOF, highlights that S. clandestina is a rich source of danshensu (4.76 mg/g DW) while S. sclarea of rosmarinic acid (15.57 mg/g DW). Mutivariate statistical analysis (PCA) of hitherto studied Salvia phenols have shown similarities in profiles between S. fruticosa and S. officinalis, while S. clandestina and S. sclarea showed distinctive profiles. Otherwise, essential oil profiles analysed by PCA are clearly different among the three productive species. The extracts from collected plants were found to be effective antioxidant in three different in vitro assays (DPPH, ABTS, FRAP and Superoxide anion scavenging activity). Thus, they can be proposed as natural ingredients in functional foods, herbal medicines or as sources of bioactive molecules.

DOI
http://doi.org/10.25135/rnp.96.18.07.119
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Salvia clandestina L. Salvia fruticosa Mill. Salvia officinalis L. Salvia sclarea L. essential oils phenolic compounds.
Available online: October 10, 2018
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