Records of Natural Products

Articles In Press

Original Article

1) A New Dopamine Derivative from Cotidius chinensis

Rec. Nat. Prod. (2020) in press ; 1 - 5
by Tiantian Xu , Lei Cheng , Shiji Xiao and Xiaohui Hou

A new dopamine derivative (1), along with three known analogues (2‒4), was isolated from the medical insect Cotidius chinensis. Their chemical structures were identified by spectral data including HR-ESI-MS, 1D and 2D NMR.

DOI
http://doi.org/10.25135/rnp.176.19.12.1503
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Cotidius chinensis Aspongopus chinensis dopamine derivative medical insect cotidione A
Available online: April 07, 2020
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Short Report

2) A New Labdane Diterpene from the Aerial Parts of Chloranthus serratus

Rec. Nat. Prod. (2020) in press ; 1 - 5
by Ming Zhao , Gang Chen , Tingting Lin and Yu Lu

A new labdane diterpene (1) and five known compounds (2-6) were isolated from the aerial parts of Chloranthus serratus. The gross structure of compound 1 was resolved by NMR and HRESIMS data. The absolute configuration of 1 was determined by comparing CD spectrum and specific rotations with those of the co-isolated known analogue 2. The known compounds were identified to be agathic acid (2), altechromone (3), chlorajapolide F (4), shizukanolide (5), and chloranthalactone E (6) by comparing the NMR data with those in the literature. ll compounds were evaluated for their inhibitions against NO production in LPS-activated RAW 264.7 macrophages, compounds 2 and 6 showed moderate inhibitions with IC50 values of 45.2 ± 1.2 and 35.3 ± 0.9 mM.

DOI
http://doi.org/10.25135/rnp.175.20.02.1559
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Chloranthus serratus labdane diterpene inhibitions NO production
Available online: April 05, 2020
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Original Article

3) Structure, Absolute Configuration and Biological Evaluation of a New Labdane Diterpenoid from Jatropha podagrica

Rec. Nat. Prod. (2020) in press ; 1 - 6
by Dongbo Zhang , Jingao Yu , Zhen Zhang , Yanni Liang , Zhishu Tang and Zheng Wang

Jatrodagricaine A (1), a new labdane-type diterpenoid, together with three known derivatives (24) were isolated from the leaves of Jatropha podagrica. Their structures were elucidated by extensive spectroscopic methods. The absolute configuration of 1 was established by its biosynthetic pathway and comparison to known compound. All compounds were investigated for their anti-inflammatory and thioredoxin reductase (TrxR) inhibitory activities. Compound 1 showed potential inhibition in terms of nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages with IC50 value of 40.6 ± 2.2 μM.

DOI
http://doi.org/10.25135/rnp.172.1912.1495
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Jatropha podagrica labdane diterpenoid anti-inflammatory activity thioredoxin reductase
Available online: April 02, 2020
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Original Article

4) New Spectinabilin and Hexadienamide Derivatives from Streptomyces sp. S012

Rec. Nat. Prod. (2020) in press ; 1 - 7
by Chunhua Lu , Zhang Zhiqiang , Zhang Xiaochun and Kang Qianjin

A new spectinabilin derivative (1) and hexadienamide (3), together with (-)-spectinabilin (2) and sarmentosamide (4), were isolated from Streptomyces sp. S012. Their structures were elucidated on the basis of spectroscopic analysis, including 1H, 13C NMR, 1H-1H COSY, HSQC, HMBC, NOESY and HRESIMS. Their antibacterial activity was also evaluated in this study.

DOI
http://doi.org/10.25135/rnp.173.19.12.1510
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Spectinabilin hexadienamide Streptomyces sp. S012 spectral data
Available online: March 17, 2020
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Short Report

5) Antimicrobial, Larvicidal Activities and Composition of the Leaf Essential Oil of Magnolia coco (Lour.) DC

Rec. Nat. Prod. (2020) in press ; 1 - 6
by Nguyen Chung , Le Huong and Isiaka Ajani Ogunwande

 The chemical constituents, antimicrobial and larvicidal activities of essential oils obtained by hydrodistillation of the leaves of Magnolia coco (Lour.) DC. are being reported. The essential oils were analyzed using Gas Chromatography-Flame Ionization Detector (GC-FID) and Gas Chromatography-Mass Spectrometry (GC-MS) while the larvicidal activity was evaluated by the protocol of the World Health Organization (WHO). The microbroth dilution assay was used for the study of antimicrobial activity. The major compounds in the oil were sabinene (35.4%) and β-pinene (16.3%). The oil exhibited 100% mortality towards Aedes albopictus at 24 h and concentrate of 50 mg/mL while maximum mortality was shown against Ae. aegypti and Culex quinquefasciatus at concentration of 100  mg/mL. The median lethal concentrations, LC50, values of 11.01, 46.46 and 87.61 mg/mL were obtained against Ae. albopictus, Ae. aegypti and Cx. quinquefasciatus respectively at 24 h. However, the LC50 values at 48 h period were 10.40, 41.98 and 53.86 mg/mL respectively. In addition, the oil exhibited antimicrobial activity against Enterococcus faecalis ATCC 299212, Staphylococcus aureus ATCC 25923, Bacillus cereus ATCC 14579 and Candida albicans ATCC 10231 with minimum inhibitory concentrations (MIC) values of 128.0, 256.0, 128.0 and 64.0 µg/mL respectively, while the IC50 values were 64.33, 128.4, 65.33 and 32.33 µg/mL respectively. These reports, the first of its kind, indicate the potentials of M. coco leaf oil as a source of antimicrobial and larvicidal agents.

DOI
http://doi.org/10.25135/rnp.174.20.02.1541
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Magnolia coco essential oil monoterpenes antimicrobial activity larvicidal activity
Available online: March 17, 2020
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Short Report

6) Essential Oil Composition of Tilia platyphyllos Scop. Collected from Different Regions of Kosovo

Rec. Nat. Prod. (2020) in press ; 1 - 6
by Nita Kelmendi , Bexhet Mustafa , Fitore Zahiri , Dashnor Nebija and Avni Hajdari

The aim of this study was to assess variation of the chemical composition of essential oils obtained from inflorescences and leaves of Tilia platyphyllos Scop. collected from five different localities in Kosovo. GC-MS/GC-FID analysis revealed the presence of 96 compounds in essential oils obtained from inflorescences of large-leaved lime with the most prominent classes including hydrocarbons, with the respective concentrations in flowers and leaves of 41.7% - 46.2% and 27.5% - 36.8%, respectively, oxygenated sesquiterpenes (12.2%-23.0% and 21.3% -31.2%, in flowers and leaves, respectively) and  fatty acids and their derivatives (8.0% - 19.6% and 18.1% – 23.1% in flowers and leaves, respectively) whereas monoterpenes were present in smaller amount. Experimental data showed that large-leaved lime is reach in different groups of volatile compounds, and this species could be further recommended for food and medicinal application.

DOI
http://doi.org/10.25135/rnp.171.19.11.1490
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
large-leaved lime essential oils principal component analysis
Available online: March 15, 2020
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Original Article

7) Pomegranate (Punica granatum L.) Peel Extract: Potential Cytotoxic Agent Against Different Cancer Cell Lines

Rec. Nat. Prod. (2020) in press ; 1 - 14
by Otilija Keta , Milena Deljanin , Vladana Petkovic , Gordana Zdunić , Teodora Janković , Jelena Živković , Aleksandra Ristic Fira , Ivan Petrović and Katarina Šavikin

The aim of the present study was to investigate effects of pomegranate peel (PP) extract on different human cancer cell lines. MTT was performed to estimate cytotoxic effects of PP extract against HTB140, HTB177, MCF7, HCT116 human cancer cell lines and MRC-5 normal fibroblasts. Clonogenic assay was used to reveal cell survival after the treatment with PP extract. Cell cycle analysis was done using flow cytometry. Wound healing assay was applied to estimate inhibitory effects of PP extract on migration of cancer cells. The results showed that PP extract expressed selective cytotoxicity for cancer cells compared to normal cell line. Analyzed cancer cell lines displayed individual variations in sensitivity to PP extract reflected through changes in clonogenic survival, cell cycle distribution and migration, which may be due to the specific nature of each tested cell line. In conclusion, PP extract exhibits good inhibitory effects on tested cancer cell lines.

DOI
http://doi.org/10.25135/rnp.170.19.11.1477
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Punica granatum L. peel extract phenolic compounds cytotoxicity cancer cells
Available online: March 15, 2020
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Original Article

8) Two New Alkaloids from Pleurotus ostreatus (Jacq. :Pers.) Roll

Rec. Nat. Prod. (2020) in press ; 1 - 7
by Lijie Zhu , Xianwei Han , Xiao Cui , Shuang Li , Liman Qiao and Ruijie Chen

Pleurotus ostreatus (Jacq. :Pers.) Roll is a grey edible mushroom (Agaricochaete), containing a variety of vitamins, minerals and different kind of secondary metabolites. Two new terpenoid indole alkaloids (Terpendole N and Terpendole O) were isolated from the fermentation of P. ostreatus. Their structures were elucidated by 1D, 2D NMR, HR-ESI-MS, and ECD.

DOI
http://doi.org/10.25135/rnp.166.19.11.1480
(DOI number will be activated after the manuscript has been available in an issue.)
Keywords
Pleurotus ostreatus (Jacq. :Pers.) Roll alkaloids spectroscopic analyses
Available online: February 17, 2020
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