JOURNAL 133
Journal of Chemical Metrology
VOLUME & ISSUE
Year: 2018 Issue: 1 January-June
Year: 2018 Issue: 1 January-June
PAGES
p.70 - 78
p.70 - 78
STATISTICS
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Viewed 2694 times.
GRAPHICAL ABSTRACT
ABSTRACT
In this study, an ID-LC-MS method was developed and validated for the determination of 14 sulfonamides in milk samples. Recovery results were found to be in the range of 91%-114% for milk samples. The relative measurement uncertainty was between 7.5%- 12.7%. Validated method was performed on milk samples obtained from market and street vendors. The amount of sulfonamides in the analyzed samples was found to be below the legal limits (Sulfamethazine: 6.46±0.76 ng/g and sulfisoxazole: 7.3±0.71 ng/g).
KEYWORDS- Sulfonamides
- isotope dilution
- LC-MS/MS
- method validation
- uncertainty estimation