Preparation and value assignment of parabens and phenoxyethanol in cosmetic cream certified reference material

CRM Report Article

JOURNAL 2049

Journal of Chemical Metrology

VOLUME & ISSUE

Year: 2021 Issue: 1 January-June

PAGES

p.1 - 10

DOI ADDRESS

http://doi.org/10.25135/jcm.59.21.04.2049

STATISTICS

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AUTHORS

Ibrahim F. Tahoun
Eman A. Rend
Mohamed A. Gab-Allah

GRAPHICAL ABSTRACT

ABSTRACT

A new certified reference material has been developed by National Institute of Standards according to ISO Guides 30-35 and ISO 17034:2016 for preservatives in cosmetic cream to be used for validation and verification of analytical methods, proficiency testing and as internal quality control sample for quality assurance in testing laboratories. The material was prepared gravimetrically and mass fraction of each analyte was confirmed be validated liquid chromatographic method. The material along with analytes homogeneity and stability were completely evaluated. The certified value of phenoxyethanol, methyl, ethyl, propyl, and butyl paraben and their corresponding expanded uncertainties (k = 2.0) were found (0.500±0.017) %, (0.150±0.006) %, (0.051±0.003) %, (0.101±0.004) % and (0.050 ±0.003) %, respectively.

KEYWORDS

Cosmetic cream
parabens
phenoxyethanol
value assignment
reference material