JOURNAL 2049
Journal of Chemical Metrology
Year: 2021 Issue: 1 January-June
p.1 - 10
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GRAPHICAL ABSTRACT
ABSTRACT
A new certified reference material has been developed by National Institute of Standards according to ISO Guides 30-35 and ISO 17034:2016 for preservatives in cosmetic cream to be used for validation and verification of analytical methods, proficiency testing and as internal quality control sample for quality assurance in testing laboratories. The material was prepared gravimetrically and mass fraction of each analyte was confirmed be validated liquid chromatographic method. The material along with analytes homogeneity and stability were completely evaluated. The certified value of phenoxyethanol, methyl, ethyl, propyl, and butyl paraben and their corresponding expanded uncertainties (k = 2.0) were found (0.500±0.017) %, (0.150±0.006) %, (0.051±0.003) %, (0.101±0.004) % and (0.050 ±0.003) %, respectively.
KEYWORDS- Cosmetic cream
- parabens
- phenoxyethanol
- value assignment
- reference material