A simple UFLC method for determination of montelukast in human plasma

Short Report

JOURNAL 3262

Journal of Chemical Metrology

VOLUME & ISSUE

Year: 2024 Issue: 2 July-December

PAGES

p.198 - 202

DOI ADDRESS

http://doi.org/10.25135/jcm.114.2407.3262

STATISTICS

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AUTHORS

Armağan Önal
Cem Onal
S. Evrim Kepekci Tekkeli

GRAPHICAL ABSTRACT

ABSTRACT

In this investigation, an UFLC technique utilizing fluorimetric detection was reported for the analysis of Montelukast (MON) in plasma. The method involves pre-column derivatization using 4-bromomethyl-7-methoxycoumarin (BrMmC). The calibration curve linear concentrations from 10 to 1000 ng/mL. The method exhibited an average recovery rate of 95.49%. The newly developed method was effectively utilized to assess the pharmacokinetics of Montelukast (MON) following the administration of a single 10 mg tablet to a healthy male volunteer..

KEYWORDS

Montelukast,
ultra fast liquid chromatography,
4-bromomethyl-7-methoxycoumarin
fluorimetric detection
human plasma

SUPPORTING INFORMATION

Supporting Information

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