A simple UFLC method for determination of montelukast in human plasma

Short Report

JOURNAL 3262

Journal of Chemical Metrology
VOLUME & ISSUE
Available Online: October 02,2024
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/jcm.114.2407.3262
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Armağan Önal
  • Cem Onal
  • S. Evrim Kepekci Tekkeli
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

In this investigation, an UFLC technique utilizing fluorimetric detection was reported for the analysis of Montelukast (MON) in plasma. The method involves pre-column derivatization using 4-bromomethyl-7-methoxycoumarin (BrMmC). The calibration curve linear concentrations from 10 to 1000 ng/mL. The method exhibited an average recovery rate of 95.49%. The newly developed method was effectively utilized to assess the pharmacokinetics of Montelukast (MON) following the administration of a single 10 mg tablet to a healthy male volunteer..

 KEYWORDS
  • Montelukast,
  • ultra fast liquid chromatography,
  • 4-bromomethyl-7-methoxycoumarin
  • fluorimetric detection
  • human plasma

SUPPORTING INFORMATION

Supporting Information
Download File 114-JCM-2407-3262-SI.pdf (99.54 KB)