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ZrCl4-catalyzed one-pot multi-component synthesis of hexahydropyrano pyrimidinone derivatives

Short Communication

JOURNAL 1551

Organic Communications
VOLUME & ISSUE
Year: 2020 Issue: 1 January-March
PAGES
p.28 - 32
DOI ADDRESS
http://doi.org/10.25135/acg.oc.72.20.02.1551
STATISTICS
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AUTHORS
  • Parshuram M. Pisal
  • Ajay S. Sawant
  • Vinod T. Kamble
  • Ravi Varala
  • Syed F. Adil
  • Mujeeb Khan
  • Mohammed Rafiq H. Siddiqui
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GRAPHICAL ABSTRACT

ABSTRACT

In this study, zirconium tetrachloride is used as a highly efficient catalyst for the one-pot three component reaction of 3,4-dihydro(2H)-pyran, urea and benzaldehyde in ethanol, producing corresponding hexahydropyrano pyrimidinone derivatives in good yields, with excellent diastereoselectivity. This method has various benefits such as easy availability of starting materials, lower cost, higher yield and shorter reaction time.

 

 

 KEYWORDS
  • Multi-component reactions
  • aldehydes
  • urea/thiourea
  • 3,4-dihydro(2H)-pyran
  • atalysis

SUPPORTING INFORMATION

Supporting Information
Download File A5-72-OC-2002-1551-SI.pdf (958.98 KB)