Synthesis of ɣ-glutamyl β-cyanoalanine precursor

Short Communication

JOURNAL 1660

Organic Communications

VOLUME & ISSUE

Year: 2020 Issue: 4 October-December

PAGES

p.202 - 206

DOI ADDRESS

http://doi.org/10.25135/acg.oc.89.20.05.1660

STATISTICS

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AUTHORS

Şule Şahin Ün
Ramazan Altundaş
Ahmet C. Gören

GRAPHICAL ABSTRACT

ABSTRACT

The synthesis of precursors of neurotoxic ɣ-glutamyl β-cyanoalanine was developed starting from L-Serine via through the preparation of b-cyanoalanine and glutamyl units. Coupling of these two intermediates gave methyl ester of ɣ-glutamyl β-cyanoalanine precursor.

KEYWORDS

Amino acid
β-cyanoalanin (BCA)
precursors of gGBCA
ɣ-glutamyl β-cyanoalanine (ɡGBCA)

SUPPORTING INFORMATION

Supporting Information

Download File A7-89-OC-2005-1660-SI.pdf (1.32 MB)