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Synthesis, spectral characterization, antimicrobial activity and docking studies against DNA Gyrase-A of new 4-chloro-3-nitrobenzene sulfonamide derivatives

Original Article

JOURNAL 1858

Organic Communications
VOLUME & ISSUE
Year: 2020 Issue: 4 October-December
PAGES
p.155 - 164
DOI ADDRESS
http://doi.org/10.25135/acg.oc.90.20.11.1858
STATISTICS
Viewed 1817 times.
AUTHORS
  • Pilju Choi
  • Reddi Mohan Naidu Kalla
  • Mavallur Varalakshmi
  • Chintha Venkataramaiah
  • K.Swetha Kumari
  • Jayakumar Kannali
  • D. Venkatramana Reddy
  • Chamarthi Naga Raju
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A series of new 4-chloro-3-nitrobenzene sulfonamide derivatives 3(a-j) were synthesized from 4-chloro-3-nitrobenzene sulfonyl chloride by reacting various amino acid esters and amines 2(a-j) in high yields. The structures of all the synthesized compounds were characterized by the IR, NMR (1H & 13C), mass and elemental analyses. Further, all the synthesized compounds were tested for the antimicrobial activity and docking studies were carried out with DNA Gyrase-A. Most of the compounds showed good to moderate antimicrobial activities and binding affinity towards DNA Gyrase-A structure.

 KEYWORDS
  • 4-Chloro-3-nitrobenzene
  • amino acid esters
  • antimicrobial activity
  • docking studies
  • DNA Gyrase A
  • sulfonamides

SUPPORTING INFORMATION

Supporting Information
Download File A2-90-OC-2010-1858-SI.pdf (645.24 KB)