JOURNAL 312


Records of Natural Products
VOLUME & ISSUE
Year: 2010 Issue: 3 July September
PAGES
p.149 - 155
STATISTICS
Viewed 1901 times.
AUTHORS
    Hyung-In Moon and Okpyo Zee
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


In search for antiproliferative compound against human cancer cells (A549, SK-OV-3, SK-MEL-2, XF498, HCT15), a chloroform soluble extract obtained by re-extraction of the methanol extract of whole plant of Carpesium rosulatum MlQ. (Compositae) exhibited cytotoxic activity. Four germacrane sesquiterpene lactones 2α,5-epoxy-5,10-dihydroxy-6-angeloyl-oxy-9β-isobutyloxy-germacran-8α,12-olide, 2α,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide, 2α,5-epoxy-5,10-dihydroxy-6α-angeloyloxy-9β-(3-methyl-butanoyloxy)-germacran-8α,12-olide, and 2β,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide were isolated from the chloroform extract of C . rosulatum, and 2α,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide showed the most potent cytotoxicity with IC 50 value of 6.01 μM against SK-MEL-2 .

KEYWORDS
  • Carpesium rosulatum
  • Cytotoxic activity
  • human tumor cell lines
  • SRB .