JOURNAL 437


Records of Natural Products
VOLUME & ISSUE
Year: 2011 Issue: 4 October-December
PAGES
p.324 - 327
STATISTICS
Viewed 1924 times.
AUTHORS
    Sorachai Khamsan, Boonsom Liawruangrath , Saisunee Liawruangrath, Aphiwat Teerawutkulrag , Stephen G. Pyne and Mary J. Garson
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The chemical constituents of the essential oil from Cyperus kyllingia Endl. were analyzed by a GC, GC-MS. Twenty-three compounds were identified, accounting for 93.75% of the total oil that consisted mainly of oxygenated sesquiterpenes (53.52%), particularly sesquiterpene hydrocarbons (38.97%), and carboxylic acid (1.26%). The most representative compounds were a -cadinol (19.32 %), caryophyllene oxide (12.17%), a -muurolol (11.58 %), a -humulene (9.85%), and a -atlantone (6.07%). The oil showed significant activities against Plasmodium falcipalum (K1, multi drug resistant strain) and NCI-H187 (Small Cell Lung Cancer) with the IC 50 values of 7.52 and 7.72 µg/mL, respectively. The oilexhibited highly active against Staphylococcus aureus ATCC25923 and moderately active against Escherichia coli ATCC25922, Pseudomonas aeruginosa ATCC27553, Aspergillus flavus and Candida albicans.

KEYWORDS
  • Cyperus kyllingia Endl.
  • essential oil
  • antimalarial activity
  • anticancer activity
  • antimicrobial activity