JOURNAL 501


Records of Natural Products
VOLUME & ISSUE
Year: 2012 Issue: 4 October-December
PAGES
p.356 - 367
STATISTICS
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AUTHORS
    Franco Piozzi and Maurizio Bruno
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The extracts of various marine sponges (Agelas oroides and Axinella damicornisAxinella cannabinaIrcinia spinulosaI. fasciculata, and I. variabilisDysidea avara, and Sarcotragus spinulosus) collected from different spots of the Turkish cost of the Mediterranean Sea have been evaluated for their antibacterial, antifungal, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, and acetylcholinesterase (AChE) inhibitory activities. Three compounds (oroidin, 4,5-dibromopyrrol-2-carboxylic acid, and 25-hydroxy-24-methylcholesterol) were isolated from A. oroides and tested in the same manner. The sponge extracts showed notable antimicrobial and anti-AChE activity and low DPPH scavenging activity. Oroidin was found to have moderate anti-AChE and strong radical scavenging activities. The results demonstrated that the sponge extracts exerted a variable degree of antibacterial, anti-radical, and anti-AChE activity, whereas they seemed to have similar antifungal effect. Our findings point out to the fact that the collection site has an important influence on bioactivity of the sponges.

KEYWORDS
  • Marine sponge
  • antimicrobial
  • anticholinesterase
  • radical scavenger
  • collection site.