JOURNAL 537


Records of Natural Products
VOLUME & ISSUE
Year: 2015 Issue: 2 April-June
PAGES
p.262 - 266
STATISTICS
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AUTHORS
    Rabia Raza, Zaitoon Ilyas, Sajid Ali, Muhammad Nisar, Muhammad Younas Khokhar and Jamshed Iqbal
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


This study explored antidiabetic potential of eight known pure compounds, isolated from the bark of Rhododendron arboreumInvitro studies of these compounds against α and β-glucosidases revealed them as very potent and selective inhibitors of α-glucosidase. Compound 7 (3-O-acetylursolic acid) was found to be the most potent inhibitor of α-glucosidase with 3.3±0.1µM IC 50 value which was many folds higher than standard inhibitor acarbose. Antiglycation studies of compounds showed that all compounds were also very active antiglycation agents. The studied biological properties of these compounds suggest that they are therapeutically interesting and important tools for treatment of diabetes.

KEYWORDS
  • Rhododendron arboreum
  • α-glucosidase inhibitors
  • antidiabetic
  • antiglycation

SUPPORTING INFORMATION


Supporting Information
Download File 31-RNP-1404-061_SI.pdf (385.73 KB)