JOURNAL 605


Records of Natural Products
VOLUME & ISSUE
Year: 2016 Issue: 6 November-December
PAGES
p.721 - 734
STATISTICS
Viewed 2069 times.
AUTHORS
    Faheema Siddiqui, Lubna Abidi, Lubna, Ching Fidelis Poh, Sabira Naqvi, Shaheen Faizi and Ahsana Dar Farooq
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Opuntia dillenii (Nagphana) traditionally used against inflammation and also possess analgesic effect. Thus in the present study analgesic properties of O. dillenii cladode methanol extract, its fractions obtained via vacuum liquid chromatography along with isolated α-pyrones, opuntiol and its glucoside, opuntioside were analyzed. The acetic acid-induced writhes were reduced by O. dillenii test agents with opuntioside being most effective (IC 50 26 ± 0.9 mg/kg) and equipotent to diclofenac and β-sitosterol. Consistently, it also elicited most potent effect (IC 50: 28 ± 1.1 and 24 ± 1.2 mg/kg) during early and late phases of formalin-induced paw licking, producing effect similar to diclofenac and indomethacin. It was also most effective in hot plate test. Naloxone (opioid antagonist) reversed the analgesic effects of extract and fractions but failed to antagonize the opuntiol and opuntioside analgesic effects. In conclusion, edible O. dillenii extract, its fractions, opuntiol and opuntioside reduced peripheral and centrally mediated pain via opioid dependent and independent systems. Among them opuntioside emerged as most effective analgesic possibly due to the presence of glucose moiety at position 7 of its α-pyrone ring. This is the first report of opuntiol and opuntioside analgesic effect which may serve as lead compounds in designing of new analgesics.

KEYWORDS
  • Opuntia dillenii
  • opuntiol
  • opuntioside
  • analgesic
  • inflammation
  • prostaglandins

SUPPORTING INFORMATION


Supporting Information
Download File 85-RNP-1509-192-SI.pdf (1.24 MB)