JOURNAL 206


Records of Natural Products
VOLUME & ISSUE
Year: 2017 Issue: 1 January-February
PAGES
p.63 - 68
STATISTICS
Viewed 677 times.
AUTHORS
    Takahiro Ishii, Takumi Nagamine, Binh Cao Quan Nguyen and Shinkichi Tawata
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


An ethyl acetate (EtOAc) extract of Laurencia nidifica was found to have toxic effect against brine shrimp larvae (Artemia salina). Bioassay-guided fractionation of the EtOAc extract resulted in the isolation of four known halogenated sesquiterpenes, laurinterol (1), isolaurinterol (2), aplysin (3), and a -bromocuparene (4). Their structures were established on the basis of spectral analysis and comparison with literature data. Among isolated compounds, only laurinterol showed strong toxicity against A. salina. Further experiments revealed that laurinterol also exhibited repellent activity against the maize weevil Sitophilus zeamais , insecticidal activity against the termite Reticulitermes speratus, and acetylcholinesterase (AChE) inhibitory effect . This is the first report of insecticidal and repellent activities of laurinterol.

KEYWORDS
  • Laurinterol
  • Laurencia nidifica
  • h alogenated secondary metabolites
  • brine shrimp
  • i nsecticid al activity
  • termiticidal activity

SUPPORTING INFORMATION


Download File 9-RNP-1604-365-SI.pdf (616.81 KB)