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A New Dibenzofuran from the Barks of Sorbus commixta

Short Report

JOURNAL 42

Records of Natural Products
VOLUME & ISSUE
Year: 2018 Issue: 2 March-April
PAGES
p.179 - 183
DOI ADDRESS
http://doi.org/10.25135/rnp.20.17.06.112
STATISTICS
Viewed 2124 times.
AUTHORS
    Seong Yeon Choi, Birang Jeong, Hyeon Seok Jang, Jiho Lee, Kiwon Ko, Hyunha Kim, Jua Hong, Young Soo Bae and Heejung Yang
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A new dibenzofuran derivative, 1,2,4-trimethoxydibenzofuran-3,9-diol (7), was isolated from the ethyl acetate fraction of Sorbus commixta barks, along with six known compounds, lupeol (1), betulin (2), betulinic acid (3), ursolic acid (4), b -sitosterol (5) and b -pyrufuran (6). Their structures were determined by NMR spectroscopic analysis, including of 1H and 13C NMR, 1H- 1H COSY, HSQC and HMBC spectra data. Cytotoxic activities of seven compounds were evaluated in five cancer cell lines, HEp-2, A549, MCF-7, PC-3 and SKOV-3 at the concentrations ranging from 10 to 100 m M.

 KEYWORDS
  • Sorbus commixta
  • triterpenes
  • dibenzofuran
  • 1
  • 2
  • 4-trimethoxydibenzofuran-3
  • 9-diol
  • cytotoxicity

SUPPORTING INFORMATION

Supporting Information
Download File 20-RNP-1706-112_ SI.pdf (1007.06 KB)