JOURNAL 1373


Records of Natural Products
VOLUME & ISSUE
Year: 2020 Issue: 4 July-August
PAGES
p.256 - 268
STATISTICS
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AUTHORS
  • Turgut Kılıç
  • Gülaçtı Topçu
  • Ahmet C. Gören
  • Zeynep Aydogmus
  • Ali Karagoz
  • Yasar Kemal Yildiz
  • Irfan Aslan
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


The genus Sideritis (Lamiaceae) is represented by 45 species (54 taxa) in Anatolia with high endemism ratio (74%), and Turkey is one of the gene centers of the genus along with Spain. Acetone extract of the aerial parts of Sideritis lycia afforded eight known ent-kaurene diterpenoids, structures of which have been identified as linearol, isolinearol, isosidol, sidol, siderol, sideridiol, 7-epi-candicandiol and foliol through 1H NMR, 13C NMR and mass spectroscopic analyses. Cytotoxic and antiviral activities of the acetone extract, linearol, sidol and isosidol were investigated together with insecticidal activity of species. antiviral index of linearol, isosidol and acetone extract of S. lycia were determined as 2.31, 2.01 and 2.58, respectively, except sidol. 7-Epi-candicandiol was found to be the most active diterpene against a series of cancer cell lines with ED50 values; KB (13.3 µg/mL), COL-2 (11.8 mg/mL), LU1 (17.9 mg/mL), LNCaP (14.9 mg/mL) and A2780 (9.0 mg/mL). Activity results of this study indicated that ent-kaurane diterpenes have potential to be considered as antiviral and cytotoxic lead compounds.

KEYWORDS
  • Sideritis lycia
  • diterpenoid
  • NMR and mass spectroscopy
  • antiviral
  • cytotoxic activity
  • insecticidal activity

SUPPORTING INFORMATION


Supporting Information
Download File A3-163-RNP-1908-1373-SI.pdf (513.01 KB)