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Cytotoxic Constituents from the Rhizomes of Monstera deliciosa

Short Report

JOURNAL 2390

Records of Natural Products
VOLUME & ISSUE
Year: 2023 Issue: 2-March-April
PAGES
p.372 - 376
DOI ADDRESS
http://doi.org/10.25135/rnp.352.2203.2390
STATISTICS
Viewed 2774 times.
AUTHORS
  • Marwa Elsbaey
  • Kadria F. Ahmad
  • Fathy Behery
  • Mohamed Amer
  • Mohamed Farid Lahloub
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A phytochemical study of the rhizomes of Monstera deliciosa has led to isolation of fourteen compounds (1-14) for the first time from the plant species. The structure elucidation was carried out using 1D and 2D NMR data. The cytotoxic activities of the compounds against the liver (HepG-2), larynx (Hep-2), colon (HCT-116), and breast (MCF-7) cancer cell lines were evaluated using MTT assays. Syringaresinol (6) showed remarkable IC50 values against the four tested cell lines. In addition, 9, 12, 13-trihydroxy-10-octadecenoic acid (14) was highly cytotoxic against Hep-2 and HCT-116 cell lines.

 KEYWORDS
  • Monstera
  • Araceae
  • cytotoxic
  • lignan

SUPPORTING INFORMATION

Supporting Information
Download File A18-352-RNP-2203-2390-SI.pdf (2.05 MB)